IL-4 Inhibitor |
| Catalog No.GC47450 |
IL-4 Inhibitor (compound 52) is an IL-4 inhibitor, with an EC50 of 1.81 μM.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1332184-63-0
Sample solution is provided at 25 µL, 10mM.
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IL-4 inhibitor is an inhibitor of IL-4.1 It binds to IL-4 with a Kd value of 1.8 μM and inhibits IL-4 activity in a cell-based reporter assay (EC50 = 1.81 μM). It is selective for IL-4 over IL-13 (EC50 = 18.2 μM). IL-4 inhibitor inhibits IL-4-induced STAT6 phosphorylation in THP-1 monocytes (EC50 = 3.1 μM), indicating inhibition of the IL-4-JAK1-STAT6 signaling pathway.
1.Quinnell, S.P., Leifer, B.S., Nestor, S.T., et al.A small-molecule inhibitor to the cytokine interleukin-4ACS Chem. Biol.15(10)2649-2654(2020)
Average Rating: 5 (Based on Reviews and 13 reference(s) in Google Scholar.)
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