IMP-1700 |
| Catalog No.GC48439 |
An inhibitor of bacterial DNA repair
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1458674-25-3
Sample solution is provided at 25 µL, 10mM.
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IMP-1700 is an inhibitor of bacterial DNA repair.1 It potentiates the activity of the quinolone antibiotic ciprofloxacin against methicillin-resistant S. aureus (MRSA) with a combination index value of 0.7. IMP-1700 inhibits the ciprofloxacin-induced bacterial SOS response, a process that repairs DNA damage, in a reporter assay in a concentration-dependent manner. It is also active against E. coli, as well as methicillin-resistant and -sensitive S. aureus, when used alone (EC50s = 0.5, 0.21, and 3.8 µM, respectively).
1.Lim, C.S.Q., Ha, K.P., Clarke, R.S., et al.Identification of a potent small-molecule inhibitor of bacterial DNA repair that potentiates quinolone antibiotic activity in methicillin-resistant Staphylococcus aureusBioorg. Med. Chem.27(20)114962(2019)
Average Rating: 5 (Based on Reviews and 28 reference(s) in Google Scholar.)
GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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