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KKL-10 Catalog No.GC30808

Size Price Stock Qty
10mM*1mLinDMSO
$250.00
In stock
1mg
$134.00
In stock
5mg
$312.00
In stock
10mg
$536.00
In stock
50mg
$2,053.00
In stock

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Sample solution is provided at 25 µL, 10mM.

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Chemical Properties

Cas No. 952849-76-2 SDF Download SDF
Synonyms N/A
Chemical Name N/A
Canonical SMILES O=C(C1=CC=C(Br)S1)NC2=NN=C(C3=CC=C(C)C=C3)O2
Formula C14H10BrN3O2S M.Wt 364.22
Solubility DMSO : 6.8 mg/mL (18.67 mM; Need ultrasonic) Storage Store at -20°C
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
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Background

KKL-10 is a small-molecule ribosome rescue inhibitor with broad-spectrum antimicrobial activity against bacteria.

The ribosome rescue inhibitor KKL-10 exhibits exceptional antimicrobial activity against both attenuated and fully virulent strains of F. tularensis. The minimum inhibitory concentration (MIC) against F. tularensis strain LVS and Schu S4 are 0.12 and 0.48 μg/mL, respectively. KKL-10 arrests intracellular growth of F. tularensis during all stages of infection. KKL-10 does not affect macrophage viability or function. KKL-10 produces cytotoxic effects of less than 5% at concentrations up to 17.5 μg/mL. The combination of IFN-γ stimulation and KKL-10 activity results in a reduction of the bacterial load by >99.9%. KKL-10 is also able to inhibit growth of F. tularensis inside eukaryotic cells and show no toxicity to HepG2 cells[1].

[1]. Goralski TD, et al. Inhibitors of Ribosome Rescue Arrest Growth of Francisella tularensis at All Stages of Intracellular Replication. Antimicrob Agents Chemother. 2016 May 23;60(6):3276-82.