L-Valacyclovir-d8 (hydrochloride) |
| Catalog No.GC47584 |
An internal standard for the quantification of valacyclovir
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1279033-32-7
Sample solution is provided at 25 µL, 10mM.
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L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir . L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 µM in Vero cells).1 It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.2 Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.
1.Beauchamp, L.M., Orr, G.F., de Miranda, P., et al.Amino acid ester prodrugs of acyclovirAntivir. Chem. Chemother.3(3)157-164(1992) 2.Beutner, K.R.Valacyclovir: A review of its antiviral activity, pharmacokinetic properties, and clinical efficacyAntiviral Res.28(4)281-290(1995)
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