Lipid 114 |
Catalog No.GC92259
One-Click Copy Product Info
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Lipid 114 is an ionizable cationic lipid (pKa = ~6.8) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Lipid 114 is an ionizable cationic lipid (pKa = ~6.8) that has been used in the generation of lipid nanoparticles (LNPs) for the delivery of siRNA in vitro and in vivo. Lipid 114-containing LNPs accumulate in the liver and, to a lesser extent, the kidneys in mice. LNPs containing lipid 114 and encapsulating siRNA targeting IL-1β reduce IL1B expression in activated RAW 264.7 macrophages and primary mouse macrophages in a concentration-dependent manner. Lipid 114-containing LNPs encapsulating IL-1β-targeted siRNA reduce hepatic and renal expression of Il1b, as well as decrease hepatic inflammation and damage, in a mouse model of acute liver failure induced by LPS and D-(+)-galactosamine .
| Cas No. | SDF | ||
| Chemical Name | ditetradecyl 4,8,17-tris(3-oxo-3-(tetradecyloxy)propyl)-4,8,13,17-tetraazaicosanedioate | ||
| Canonical SMILES | CCCCCCCCCCCCCCOC(CCN(CCC(OCCCCCCCCCCCCCC)=O)CCCNCCCCN(CCCN(CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)CCC(OCCCCCCCCCCCCCC)=O)=O | ||
| Formula | C95H186N4O10 | M.Wt | 1544.5143 |
| Solubility | Methyl Acetate: Soluble: ≥10 mg/mL | Storage | -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 647.5 μL | 3.2373 mL | 6.4745 mL |
| 5 mM | 129.5 μL | 647.5 μL | 1.2949 mL |
| 10 mM | 64.7 μL | 323.7 μL | 647.5 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in methyl acetate
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)