LMTK3 Inhibitor C28 (Synonyms: Lemur Tyrosine Kinase 3-IN-1; Lemur Tyrosine Kinase-IN-C28; Lemur Tyrosine Kinase 3 Inhibitor 1; Lemur Tyrosine Kinase Inhibitor C28; LMTK3-IN-1; LMTK3-IN-C28; LMTK3 Inhibitor 1) |
Catalog No.GC91967
One-Click Copy Product Info
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LMTK3 inhibitor C28 is a multi-kinase inhibitor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2764850-23-7
Sample solution is provided at 25 µL, 10mM.
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LMTK3 inhibitor C28 is a multi-kinase inhibitor.1 It inhibits lemur tyrosine kinase 3 (LMTK3), CDC-like kinase 2 (Clk2), dual-specificity tyrosine phosphorylation-regulated kinase 1α (DYRK1α), homeodomain-interacting protein kinase 2 (HIPK2), and IL-1 receptor-associated kinase 4 (IRAK4; IC50s = 67, 5, 6, 48, and 41 nM, respectively), among others. LMTK3 inhibitor C28 is selective for these kinases over a panel of 122 kinases at 1 ?M. It induces proteasomal degradation of LMTK3 in MCF-7, T47D, and MDA-MB-231 breast cancer cells when used at concentrations of 5 or 10 ?M. LMTK3 inhibitor C28 (10 ?M) reduces the levels of IRAK4, estrogen receptor α (ERα), phosphorylated tropomyosin-related kinase A (TrkA), and HIPK2 in T47D cells. It induces induces apoptosis in MCF-7, T47D, and MDA-MB-231 cells when used at a concentration of 10 ?M. In vivo, LMTK3 inhibitor C28 (10 mg/kg per day) reduces tumor growth and volume in an MDA-MB-231 mouse xenograft model.
References:
[1]. Ditsiou, A., Cilibrasi, C., Simigdala, N., et al.The structure-function relationship of oncogenic LMTK3Sci. Adv.6(46)eabc3099(2020).
| Cas No. | 2764850-23-7 | SDF | |
| Synonyms | Lemur Tyrosine Kinase 3-IN-1; Lemur Tyrosine Kinase-IN-C28; Lemur Tyrosine Kinase 3 Inhibitor 1; Lemur Tyrosine Kinase Inhibitor C28; LMTK3-IN-1; LMTK3-IN-C28; LMTK3 Inhibitor 1 | ||
| Chemical Name | 6-(4-pyridinyl)-3-[3-(trifluoromethoxy)phenyl]-imidazo[1,2-b]pyridazine | ||
| Canonical SMILES | FC(F)(OC1=CC=CC(C2=CN=C3C=CC(C4=CC=NC=C4)=NN32)=C1)F | ||
| Formula | C18H11F3N4O | M.Wt | 356.3 |
| Solubility | DMSO: Slightly soluble: 0.1-1 mg/ml,Ethanol: Slightly soluble: 0.1-1 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.8066 mL | 14.0331 mL | 28.0662 mL |
| 5 mM | 561.3 μL | 2.8066 mL | 5.6132 mL |
| 10 mM | 280.7 μL | 1.4033 mL | 2.8066 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)