MC 1046 (Synonyms: Impurity A of Calcipotriol) |
Catalog No.GC16982
One-Click Copy Product Info
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Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 126860-83-1
Sample solution is provided at 25 µL, 10mM.
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MC 903 has been found to be a potent inducer of cell differentiation and to inhibit proliferation and DNA-synthesis of cells possessing the receptor for 1,25(OH)2D3. MC 1046 is the metabolite of calcipotrioI (MC 903), which is a novel analogue of the physiologically active metabolite of vitamin D3.
In vitro: The biological effects on the U937 cells of the two major metabolites of MC 903 (MC 1046 and MC 1080) were investigated. Results showed that the metabolites had effects that were more than 100 times weaker than those of the parent compound [1].
In vivo: MC 903 is a novel analogue of the physiologically active metabolite of 1,25(OH)2D3. Unlike the similar effects on cell proliferation and cell differentiation in vitro, MC 903 has 100-200 times less effect on calcium metabolism in vivo. Moreover, rat study indicats that the effect of MC 903 on proliferative disorders, its fast elimination and the formation of inactive metabolites makes MC 903 suitable for topical treatment of psoriasis [1].
Clinical trial: No clinical data are available for MC 1046 and its analogues.
Reference:
[1] Kissmeyer AM, Binderup L. Calcipotriol (MC 903): pharmacokinetics in rats and biological activities of metabolites. A comparative study with 1,25(OH)2D3. Biochem Pharmacol. 1991;41(11):1601-6.
| Cas No. | 126860-83-1 | SDF | |
| Synonyms | Impurity A of Calcipotriol | ||
| Chemical Name | (E,4R)-4-[(1R,4E,7aR)-4-[(2Z)-2-[(3S,5R)-3,5-dihydroxy-2-methylidenecyclohexylidene]ethylidene]-7a-methyl-2,3,3a,5,6,7-hexahydro-1H-inden-1-yl]-1-cyclopropylpent-2-en-1-one | ||
| Canonical SMILES | CC(C=CC(=O)C1CC1)C2CCC3C2(CCCC3=CC=C4CC(CC(C4=C)O)O)C | ||
| Formula | C27H38O3 | M.Wt | 410.59 |
| Solubility | Soluble in DMSO | Storage | 4°C, protect from light, stored under nitrogen,unstable in solution, ready to use. |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.4355 mL | 12.1776 mL | 24.3552 mL |
| 5 mM | 487.1 μL | 2.4355 mL | 4.871 mL |
| 10 mM | 243.6 μL | 1.2178 mL | 2.4355 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)