mGlu2 agonist |
Catalog No.GC11954 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1311385-32-6
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR
References:
[1]. http://clinicaltrials.gov/ct2/show/NCT01383967
[2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.
[3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto
[4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.
[5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate
Cas No. | 1311385-32-6 | SDF | |
Chemical Name | (1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; azane; hydrate | ||
Canonical SMILES | CC(C(=O)NC1(CC(C2C1C2C(=O)O)SC3=NC=NN3)C(=O)O)N.N.O | ||
Formula | C13H22N6O6S | M.Wt | 390.42 |
Solubility | Soluble in DMSO | Storage | Store at -20°C |
General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. |
Prepare stock solution | |||
1 mg | 5 mg | 10 mg | |
1 mM | 2.5613 mL | 12.8067 mL | 25.6134 mL |
5 mM | 0.5123 mL | 2.5613 mL | 5.1227 mL |
10 mM | 0.2561 mL | 1.2807 mL | 2.5613 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Average Rating: 5
(Based on Reviews and 30 reference(s) in Google Scholar.)GLPBIO products are for RESEARCH USE ONLY. Please make sure your review or question is research based.
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