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mGlu2 agonist

Catalog No.GC11954

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mGlu2 agonist Chemical Structure

Cas No.: 1311385-32-6

Size Price Stock Qty
5mg
$195.00
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10mg
$243.00
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50mg
$621.00
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200mg
$1,470.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

LY2979165 is a mGlu2 agonist, which is a novel potent agent that is used as anti-depressants.IC50 Value:Target: mGluR

References:
[1]. http://clinicaltrials.gov/ct2/show/NCT01383967
[2]. Hanna L, Ceolin L, Lucas S, Monn J, Johnson B, Collingridge G, Bortolotto Z, Lodge D.Differentiating the roles of mGlu2 and mGlu3 receptors using LY541850, an mGlu2 agonist/mGlu3 antagonist.Neuropharmacology. 2012 Mar 15.
[3]. Ceolin L, Kantamneni S, Barker GR, Hanna L, Murray L, Warburton EC, Robinson ES, Monn JA, Fitzjohn SM, Collingridge GL, Bortolotto ZA, Lodge D.Study of novel selective mGlu2 agonist in the temporo-ammonic input to CA1 neurons reveals reduced mGlu2 recepto
[4]. Liu W, Downing AC, Munsie LM, Chen P, Reed MR, Ruble CL, Landschulz KT, Kinon BJ, Nisenbaum LK.Pharmacogenetic analysis of the mGlu2/3 agonist LY2140023 monohydrate in the treatment of schizophrenia.Pharmacogenomics J. 2012 Jun;12(3):246-54.
[5]. Dominguez C, Prieto L, Valli MJ, Massey SM, Bures M, Wright RA, Johnson BG, Andis SL, Kingston A, Schoepp DD, Monn JA.Methyl substitution of 2-aminobicyclo[3.1.0]hexane 2,6-dicarboxylate (LY354740) determines functional activity at metabotropic glutamate

Chemical Properties

Cas No. 1311385-32-6 SDF
Chemical Name (1R,2R,4S,5R,6R)-4-[[(2S)-2-aminopropanoyl]amino]-2-(1H-1,2,4-triazol-5-ylsulfanyl)bicyclo[3.1.0]hexane-4,6-dicarboxylic acid; azane; hydrate
Canonical SMILES CC(C(=O)NC1(CC(C2C1C2C(=O)O)SC3=NC=NN3)C(=O)O)N.N.O
Formula C13H22N6O6S M.Wt 390.42
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.5613 mL 12.8067 mL 25.6134 mL
5 mM 0.5123 mL 2.5613 mL 5.1227 mL
10 mM 0.2561 mL 1.2807 mL 2.5613 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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