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ML-178 (Synonyms: CID 44620892,CYM 50179,SID 87544119)

Catalog No.GC10433

ML-178 (compound 22n) is a potent and selective S1P4-R (Sphingosine-1-phosphate4 receptor) agonist with an EC50 of 46 nM.

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ML-178 Chemical Structure

Cas No.: 1355026-47-9

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1mg
$38.00
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5mg
$102.00
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10mg
$176.00
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25mg
$352.00
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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

ML-178 is a novel and selective S1P4 activator with EC50 value of 46.3 nM [1].

Sphingosine-1-phosphate (S1P) is an extracellular lipid mediator released by activated blood platelets that serves to influence heart rate, coronary artery caliber, endothelial integrity, lung epithelial integrity and lymphocyte recirculation through five of the S1P receptors (S1P1/EDG-1, S1P2/EDG-5, S1P3/EDG-3, S1P4/EDG-6, and S1P5/EDG-8). S1P4 receptor is coupled to Gαi and Gαo G proteins and activates ERK, MAPK and PLC downstream pathways [1].

ML-178 is a novel and selective S1P4 activator. ML178 activated S1P4 receptor with an EC50 of 46.3 nM, and is inactive against other members of the receptor family, with EC50s > 50 μM against S1P1, S1P2, S1P3, and S1P5 receptors. ML178 was inhibited by an S1P4 receptor-selective antagonist with an IC50 of 0.83 μM. ML178 was nontoxic to U2OS cells with a CC50 of > 20 μM. ML178 was generally inactive against a broad array of off targets, including receptors, transporters, or ion channels [1].

Reference:
[1].  Guerrero M, Urbano M, Velaparthi S, et al. Probe Development Efforts to Identify Novel Agonists of the Sphingosine 1-phosphate Receptor 4 (S1P4). Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.2010 Oct 12 [updated 2011 Dec 12].

Chemical Properties

Cas No. 1355026-47-9 SDF
Synonyms CID 44620892,CYM 50179,SID 87544119
Chemical Name 2,6-dibromo-3-[2-(2,4-dichlorophenoxy)ethoxy]-pyridine
Canonical SMILES ClC1=CC(Cl)=C(OCCOC2=C(Br)N=C(Br)C=C2)C=C1
Formula C13H9Br2Cl2NO2 M.Wt 441.9
Solubility ≤15mg/ml in DMSO;30mg/ml in dimethyl formamide Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 2.263 mL 11.3148 mL 22.6296 mL
5 mM 0.4526 mL 2.263 mL 4.5259 mL
10 mM 0.2263 mL 1.1315 mL 2.263 mL
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