(+)-Muscarine (chloride) (Synonyms: (+)-Muscarine chloride) |
Catalog No.GC18746
One-Click Copy Product Info
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(+)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2303-35-7
Sample solution is provided at 25 µL, 10mM.
(+)-Muscarine is an agonist of muscarinic acetylcholine receptors that was originally found in A. muscaria.[1] It induces spasms in isolated intestinal ileum from mouse, guinea pig, rabbit, dog, monkey, and horse, contraction of longitudinal uterine and bladder muscle strips from mouse, guinea pig, rabbit, rat, horse, and dog, and slows the heart rate of isolated guinea pig and rabbit atria. In vivo, (+)-muscarine induces bronchoconstriction in guinea pigs and rabbits as well as respiratory depression in rabbits and cats with minimum active doses (MADs) ranging from 1 to 5 μg/kg. It reduces blood pressure in cats, dogs, and rabbits and induces uterine, bladder, and intestinal contraction in cats and dogs. (+)-Muscarine (0.005-0.01 mg/kg) increases circling and pacing behaviors and induces fear aggression in cats.[2] It has antinociceptive activity in rats in the hot plate and tail-flick tests. [3] (+)-Muscarine also inhibits acetylcholinesterase (Ki = 220 μM).[4]
Reference:
[1]. Fraser, P.J. Pharmacological actions of pure muscarine chloride Br. J. Pharmacol. Chemother. 12(1), 47-52 (1957).
[2]. Beleslin, D.B., and Samardzić, R. Muscarine- and carbachol-induced aggressions: Fear and irritable kinds of aggressions Pyschopharmacology (Berl.) 55(3), 233-236 (1977).
[3]. Iwamoto, E.T., and Marion, L. Characterization of the antinociception produced by intrathecally administered muscarinic agonists in rats J. Pharmacol. Exp. Ther. 266(1), 329-338 (1993).
[4]. Witkop, B., Durant, R.C., and Friess, S.L. Acetylcholinesterase inhibitory activities of muscarine and muscarone derivatives Experientia 15(8), 300-301 (1959).
| Cas No. | 2303-35-7 | SDF | |
| Synonyms | (+)-Muscarine chloride | ||
| Chemical Name | 2,5-anhydro-1,4,6-trideoxy-6-(trimethylammonio)-D-ribo-hexitol, monochloride | ||
| Canonical SMILES | C[C@H]1[C@H](O)C[C@@H](C[N+](C)(C)C)O1.[Cl-] | ||
| Formula | C9H20NO2.Cl | M.Wt | 209.7 |
| Solubility | 50mg/mL in water | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.7687 mL | 23.8436 mL | 47.6872 mL |
| 5 mM | 953.7 μL | 4.7687 mL | 9.5374 mL |
| 10 mM | 476.9 μL | 2.3844 mL | 4.7687 mL |
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 32 reference(s) in Google Scholar.)