Naperiglipron (Synonyms: LY3549492) |
Catalog No.GC78443
One-Click Copy Product Info
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Naperiglipron (LY3549492) (Example 2) is aGlucagon-like peptide 1 receptor (GLP-1R)agonist with anEC50of 1.14 nM for hGLP-1R.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2572566-11-9
Sample solution is provided at 25 µL, 10mM.
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Naperiglipron (LY3549492) (Example 2) is aGlucagon-like peptide 1 receptor (GLP-1R)agonist with anEC50of 1.14 nM for hGLP-1R. Naperiglipron significantly decreases the level of blood glucose in GLP-1R knock-in mouse models. Naperiglipron inhibitsPDE10A1enzyme activity (IC50: 7.43 μM) with a weak hERG inhibitory activity. Naperiglipron can be used for type II diabetes mellitus (T2DM) and obesity research[1].
References:
[1].Coates D A, et al. Glucagon-like peptide 1 receptor agonists. WO2020263695A1. 2020-12-30.
| Cas No. | 2572566-11-9 | SDF | |
| Synonyms | LY3549492 | ||
| Formula | C33H26F2N4O4 | M.Wt | 580.58 |
| Solubility | Storage | -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.7224 mL | 8.6121 mL | 17.2242 mL |
| 5 mM | 344.5 μL | 1.7224 mL | 3.4448 mL |
| 10 mM | 172.2 μL | 861.2 μL | 1.7224 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)