Omeprazole sulfone-d3 (Synonyms: OMEP sulfone-d3, OMP sulfone-d3, OMZ sulfone-d3) |
| Catalog No.GC47826 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2749628-17-7
Sample solution is provided at 25 µL, 10mM.
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Omeprazole sulfone-d3 is intended for use as an internal standard for the quantification of omeprazole sulfone by GC- or LC-MS. Omeprazole sulfone is the major metabolite of the gastric proton pump inhibitor, omeprazole . It is produced by cytochrome P450 (CYP)3A4 sulfoxidation of esomeprazole magnesium and is found in plasma.1 Omeprazole sulfone has been shown to act as a reversible direct-acting and metabolism-dependent inhibitor of CYP2C19 in pooled human liver microsomes (IC50 = 18 µM).2
1.ÄbelÖ, A., Andersson, T.B., Antonsson, M., et al.Stereoselective metabolism of omeprazole by human cytochrome P450 enzymesDrug Metab. Dispos.28(8)966-972(2000) 2.Ogilvie, B.W., Yerino, P., Kazmi, F., et al.The proton pump inhibitor, omeprazole, but not lansoprazole or pantoprazole, is a metabolism-dependent inhibitor of CYP2C19: Implications for coadministration with clopidogrelDrug Metab. Dispos.39(11)2020-2033(2011)
Average Rating: 5 (Based on Reviews and 24 reference(s) in Google Scholar.)
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