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Oxocarbazate

(Synonyms: Oxocarbazate; CID 23631927; CID23631927; CID-23631927;) Catalog No.: GB62275

Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L.

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Oxocarbazate Chemical Structure

Cas No.:1014405-03-8

Size Price Stock Qty
5mg
$150.00
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10mg
$250.00
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25mg
$450.00
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50mg
$750.00
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100mg
$1,250.00
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200mg
$1,750.00
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Sample solution is provided at 25 µL, 10mM.

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Quality Control & SDS

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Background

Oxocarbazate, also known as CID23631927, is an inhibitor of human cathepsin L. In the cathepsin L inhibition assay, The oxocarbazate caused a time-dependent 17-fold drop in IC50 from 6.9 nM (no preincubation) to 0.4 nM (4-h preincubation). Slowly reversible inhibition was demonstrated in a dilution assay. CID23631927 demonstrate activity in blocking both SARS-CoV (IC50 = 273 nM) and Ebola virus (IC50 = 193 nM) entry into human embryonic. CID 23631927 was a subnanomolar, slow-binding, reversible inhibitor of human cathepsin L that blocked SARS-CoV and Ebola pseudotype virus entry in human cells. Inhibition of cathepsin L thus holds promise for therapeutic intervention for both SARS-CoV and Ebola virus infection.

Chemical Properties

Cas No. 1014405-03-8 SDF
Synonyms Oxocarbazate; CID 23631927; CID23631927; CID-23631927;
Canonical SMILES O=C(NNC(OCC(N1CCCC2=C1C=CC=C2)=O)=O)[C@@H](NC(OC(C)(C)C)=O)CC3=CNC4=C3C=CC=C4
Formula C28H33N5O6 M.Wt 535.6
Solubility Soluble in DMSO Storage Store at -20℃
General tips For obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.Stock solution can be stored below -20℃ for several months.
Shipping Condition Evaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request

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Average Rating: 5 ★★★★★ (Based on Reviews and 30 reference(s) in Google Scholar.)

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