PLX 647 dihydrochloride |
| Catalog No.GC50099 |
Potent dual Fms/KIT inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1779796-38-1
Sample solution is provided at 25 µL, 10mM.
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Potent dual KIT/Fms inhibitor (IC50 values are 16 and 28 nM respectively). Inhibits BCR-FMS cell proliferation and osteoclast differentiation in vitro (IC50 values are 92 and 170 nM respectively). Attenuates LPS-induced TNFα and IL-6 release, mast cell activation and macrophage kidney proliferation in vivo.
Zhang et al (2013) Design and pharmacology of a highly specific dual FMS and KIT kinase inhibitor. Proc.Natl.Acad.Sci.U.S.A. 110 5689 PMID:23493555
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)
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