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Home >> Signaling Pathways >> Membrane Transporter/Ion Channel >> EAAT2

EAAT2

Excitatory amino acid transporter 2 (EAAT2) is the major glutamate transporter and functions to remove glutamate from synapses. An increase in EAAT2 protein expression and function may provide a means to prevent insufficient glutamate reuptake and consequently reduce neuronal damage.

The glial glutamate transporter EAAT2 plays a major role in glutamate clearance. EAAT2 can be upregulated by transcriptional or translational activation.EAAT2 is a potential target for the prevention of excitotoxicity.

Targets for  EAAT2

Products for  EAAT2

  1. Cat.No. Product Name Information
  2. GC38472 DL-TBOA An EAAT inhibitor DL-TBOA Chemical Structure
  3. GC64288 EAAT2 activator 1 EAAT2 activator 1 is the potent activator of excitatory amino acid transporter 2 (EAAT2). EAAT2 activator 1 Chemical Structure
  4. GC31075 GT 949 A positive allosteric modulator of EEAT2 GT 949 Chemical Structure
  5. GC10875 LDN 212320

    LDN-0212320; OSU-0212320

     increases expression of glutamate transporter EAAT2 LDN 212320 Chemical Structure
  6. GC13659 WAY 213613 EAAT2 (GLT-1) inhibitor WAY 213613 Chemical Structure
  7. GC38524 WAY-213613 hydrochloride WAY-213613 (hydrochloride) is a potent and selective human EAAT2 inhibitor. WAY-213613 hydrochloride Chemical Structure

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