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Proteases

Proteases - Signaling Pathways | GlpBio

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Proteases is a general term for a class of enzymes that hydrolyze protein peptide chains. According to the way they degrade polypeptides, they are divided into two categories: endopeptidases and telopeptidases. The former can cut the large molecular weight polypeptide chain from the middle to form prions and peptones with smaller molecular weights; the latter can be divided into carboxypeptidase and aminopeptidase, which respectively remove the peptide from the free carboxyl terminus or free amino terminus of the polypeptide one by one. Chain hydrolysis produces amino acids.

A general term for a class of enzymes that hydrolyze peptide bonds in proteins. According to the way they hydrolyze polypeptides, they can be divided into endopeptidases and exopeptidases. Endopeptidase cleaves the interior of the protein molecule to form smaller molecular weight peptones and peptones. Exopeptidase hydrolyzes peptide bonds one by one from the end of the free amino group or carboxyl group of protein molecules, and frees amino acids, the former is aminopeptidase and the latter is carboxypeptidase. Proteases can be classified into serine proteases, sulfhydryl proteases, metalloproteases and aspartic proteases according to their active centers and optimum pH. According to the optimum pH value of its reaction, it is divided into acidic protease, neutral protease and alkaline protease. The proteases used in industrial production are mainly endopeptidases.

Proteases are widely found in animal offal, plant stems and leaves, fruits and microorganisms. Microbial proteases are mainly produced by molds and bacteria, followed by yeast and actinomycetes.

Enzymes that catalyze the hydrolysis of proteins. There are many kinds, the important ones are pepsin, trypsin, cathepsin, papain and subtilisin. Proteases have strict selectivity for the reaction substrates they act on. A protease can only act on certain peptide bonds in protein molecules, such as the peptide bonds formed by the hydrolysis of basic amino acids catalyzed by trypsin. Proteases are widely distributed, mainly in the digestive tract of humans and animals, and are abundant in plants and microorganisms. Due to limited animal and plant resources, the industrial production of protease preparations is mainly prepared by fermentation of microorganisms such as Bacillus subtilis and Aspergillus terrestris.

Research Areas

Products Related to Proteases(4550)

  • GC79071 structure
    GC79071Apidaecin IA acetate
    Purity: >98.00%

    Apidaecin IA acetate is a basic peptide.

  • GC79072 structure
    GC79072MS6076
    Purity: >98%

    MS6076 is a mitochondrial protease ClpP agonist.

  • GC79073 structure
    GC79073HSF1-IN-2
    CAS: 304453-52-9
    Purity: >98.00%

    HSF1-IN-2 (Compound 0048) is a HSF1 inhibitor.

  • GC79074 structure
    GC79074HSP70/DnaK substrate peptide TFA
    Purity: >98.00%

    HSP70/DnaK substrate peptide TFA is a short peptide that the HSP70/DnaK molecular chaperone can bind and act on.

  • GC79075 structure
    GC79075NVS1.1
    Purity: >98%

    NVS1.1 is an orally active, blood-brain barrier-penetrant eRF1 degrader.

  • GC79077 structure
    GC79077DDO-6600
    CAS: 2640292-37-9
    Purity: >98.00%

    DDO-6600 is a covalent Hsp90 inhibitor.

  • GC79103 structure
    GC79103Berzosertib hydrochloride
    CAS: 1428935-04-9
    Purity: >98.50%

    Berzosertib (VE-822) hydrochloride is an orally active, CNS-penetrant, and selective ATR kinase inhibitor.

  • GC79111 structure
    GC79111CK2-TN03
    CAS: 313226-24-3
    Purity: >98.00%

    CK2-TN03 is an ATP-competitive casein kinase 2 ( CK2 ) inhibitor, with an IC 50 of 165 nM and a K i of 20 nM.

  • GC79144 structure
    GC79144MC3817 free base
    Purity: >98%

    MC3817 free base is a selective DNMT1 inhibitor.

  • GC79145 structure
    GC79145MC3817
    Purity: >99.50%

    MC3817 is a selective DNMT1 inhibitor.

  • GC79147 structure
    GC79147HLC40
    Purity: >99.50%

    HLC40 is a MLL1 histone methyltransferase inhibitor with an IC 50 of 0.82 μM by binding to WDR5.

  • GC79165 structure
    GC79165Snail IN-1
    CAS: 3083216-69-4
    Purity: >98.00%

    Snail IN-1 is an orally active Snail inhibitor with a Ka of 0.36 μM.Snail IN-1 disrupts Snail - CBP interaction, accelerates Snail protein degradation, reduces Snail acetylation, increases Snail polyubiquitination, and selectively downregulates Snail protein without altering other EMT transcription factors.Snail IN-1 reduces atherosclerotic plaque burden, modulates inflammation and plaque stability factors, downregulates CCL5, CXCL10, MMP2, and MMP9, and upregulates α-smooth muscle actin.Snail IN-1 exerts anti-inflammatory and plaque-stabilizing properties.Snail IN-1 can be used for the research of atherosclerosis [1] .

  • GC79177 structure
    GC79177AMPK activator 18
    CAS: 1364692-88-5
    Purity: >98.00%

    AMPK activator 18 is a potent allosteric activator of AMPK complexes containing the β2 isoform.

  • GC79302 structure
    GC79302CCKBR agonist-1
    CAS: 2923120-30-1
    Purity: >98.00%

    CCKBR agonist-1 (Compound 3r1) is a Gq-protein-preferring cholecystokinin B receptor ( CCKBR ) agonist with an EC 50 of 35 pM.

  • GC79337 structure
    GC79337ZSTK3744
    Purity: >98.00%

    ZSTK3744 is an aryl hydrocarbon receptor ( AhR ) agonist.

  • GC79397 structure
    GC793972'2'-cGAMP disodium
    Purity: >99.50%

    2'2'-cGAMP disodium, a synthetic CDN, binds STING in the immune response, inducing IFN-β. 2'2'-cGAMP disodium binds weaker binding to STING than 2'3'-cGAMP but stronger than other CDNs [1] .

  • GC79423 structure
    GC79423IL13Rα2 D1
    CAS: 2319573-67-4
    Purity: >99.00%

    IL13Rα2 D1 is an effective IL-13/IL13Rα2 signaling axis inhibitor.

  • GC79451 structure
    GC79451JP-11646
    CAS: 1902983-63-4
    Purity: >98.50%

    JP-11646 is a pan-PIM inhibitor with increased potency against PIM2 ( IC 50 = 0.5 nM).

  • GC79464 structure
    GC79464STA-013
    Purity: >99.00%

    STA-013 is a EphB tyrosine kinase inhibitor.

  • GC79475 structure
    GC79475MKK7-JNK activator 1
    CAS: 3100092-62-1
    Purity: >99.50%

    MKK7-JNK activator 1 (Compound 10) is a MKK7-JNK pathway activator.

  • GC79479 structure
    GC79479VU6083859
    Purity: >99.50%

    VU6083859 is a blood-brain barrier-permeable TAOK1 inhibitor with an IC 50 of 158 nM.

  • GC79490 structure
    GC79490Cerebellin TFA
    Purity: >95.00%

    Cerebellin TFA is a neuromodulatory hexadecapeptide that serves as a marker for Purkinje cell maturation.

  • GC79492 structure
    GC79492ML077
    CAS: 1135304-61-8
    Purity: >98%

    ML007 is a selective antagonist targeting the neuron-specific potassium-chloride co-transporter 2 ( KCC2 ) with an IC 50 for KCC2 is 537 nM, while its inhibitory activity on KCC1 is extremely weak ( IC 50 > 50 μM).

  • GC79552 structure
    GC79552XZA-1
    CAS: 1282141-20-1
    Purity: >99.50%

    XZA-1 is a 3-hydroxyacyl-coenzyme A dehydrogenase ( HADH ) activator.