Resolvin E1-d4 (Synonyms: RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4) |
| Catalog No.GC48044 |
A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Resolvin E1-d4 (RvE1-d4) is intended for use as an internal standard for the quantification of RvE1 by GC- or LC-MS. RvE1 is a trihydroxy eicosapentaenoic acid metabolite that has been identified in mouse inflammatory exudates and in human plasma when subjects are treated with both aspirin and supplemental EPA.1,2,3 RvE1 promotes inflammatory resolution in numerous disease models, including experimental colitis, asthma, atherosclerosis, type 2 diabetes, and HSV-1-induced stromal keratitis.4,5,6,7,8,9,10
1.Serhan, C.N., Clish, C.B., Brannon, J., et al.Novel functional sets of lipid-derived mediators with antiinflammatory actions generated from omega-3 fatty acids via cyclooxygenase 2-nonsteroidal antiinflammatory drugs and transcellular processingJournal of Experimental Medicine192(8)1197-1204(2000) 2.Serhan, C.N., Hong, S., Gronert, K., et al.Resolvins: A family of bioactive products of ω-3 fatty acid transformation circuits by aspirin treatment that counter proinflammation signalsJ. Exp. Med.196(8)1025-1037(2002) 3.Arita, M., Bianchini, F., Aliberti, J., et al.Sterochemical assignment, antiinflammatory properties, and receptor for the omega-3 lipid mediator resolvin E1Journal of Experimental Medicine201(5)713-722(2005) 4.Arita, M., Yoshida, M., Hong, S., et al.Resolvin E1, an endogenous lipid mediator derived from omega-3 eicosapentaenoic acid, protects against 2,4,6-trinitrobenzene sulfonic acid-induced colitisProceedings of the National Academy of Sciences of the United States of America102(21)7671-7676(2005) 5.Aoki, H., Hisada, T., Ishizuka, T., et al.Resolvin E1 dampens airway inflammation and hyperresponsiveness in a murine model of asthmaBiochemical and Biophysical Research Communications367509-515(2008) 6.Haworth, O., Cernadas, M., and Levy, B.D.NK cells are effectors for resolvin E1 in the timely resolution of allergic airway inflammationJournal of Immunology186(11)6129-6135(2011) 7.Campbell, E.K., MacManus, C.F., Kominsky, D.J., et al.Resolvin E1-induced intestinal alkaline phosphatase promotes resolution of inflammation through LPS detoxificationProceedings of the National Academy of Sciences of the United States of America107(32)14298-14303(2010) 8.Hasturk, H., Abdallah, R., Kantarck, A., et al.Resolvin E1 (RvE1) attenuates atherosclerotic plaque formation in diet and inflammation-induced atherogenesisArteriosclerosis, Thrombosis, and Vascular Biology35(5)1123-1133(2015) 9.Herrera, N.S., Hasturk, H., Kantarck, A., et al.Impact of resolvin E1 on murine neutrophil phagocytosis in type 2 diabetesInfection and Immunity83(2)792-801(2015) 10.Rajasagi, N.K., Reddy, P.B.J., Suryawanshi, A., et al.Controlling herpes simplex virus-induced ocular inflammatory lesions with the lipid-derived mediator resolvin E1J. Immunol.186(3)1735-1746(2011)
| Cas No. | N/A | SDF | |
| Synonyms | RvE1d4, 5S,12R,18R-trihydroxy-EPA-d4, 5S,12R,18R-trihydroxy-6Z,8E,10E,14Z,16E-EPA-d4, 5,12,18R-triHEPE-d4 | ||
| Canonical SMILES | CC[C@@H](O)/C=C/C([2H])=C([2H])\C[C@@H](O)/C=C/C=C/C([2H])=C([2H])\[C@@H](O)CCCC(O)=O | ||
| Formula | C20H26D4O5 | M.Wt | 354.5 |
| Solubility | DMF: 50 mg/ml,Ethanol: 50 mg/ml,PBS (pH 7.2): 0.05 mg/ml | Storage | Store at -80°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 2.8209 mL | 14.1044 mL | 28.2087 mL |
| 5 mM | 0.5642 mL | 2.8209 mL | 5.6417 mL |
| 10 mM | 0.2821 mL | 1.4104 mL | 2.8209 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 2 reference(s) in Google Scholar.)
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