SAINT C-18 (Synonyms: SAINT-2,SAINT-7,SAINT-18,Synthetic Amphiphile INTeraction C-18) |
Catalog No.GC91556
One-Click Copy Product Info
|
SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 187587-97-9
Sample solution is provided at 25 µL, 10mM.
_1-3.$$$39978408@51.jpg');)
_1-9.$$$38538795@65.jpg');)
_1-9.$$$39112701@51.jpg');)
_1-7.$$$37316672@70.jpg');)
_366-372.$$$36198801@70.jpg');)
.$$$38565142@65.jpg');)
_1867-1883.$$$33248023@67.jpg');)
_eads6055.$$$39977546@45.jpg');)
_eadm9805.$$$40080571@45.jpg');)
_eadj3020.$$$39666821@45.jpg');)
_1-20.$$$39757301@28.jpg');)
_1-24.$$$38898113@28.jpg');)
_273-287.$$$36806353@46.jpg');)
_1-16.$$$37156877@44.jpg');)
_1-19.$$$37460805@44.jpg');)
_1291-1307.$$$34518654@46.jpg');)
SAINT C-18 is a cationic lipid that has been used in the formation of liposomes for the delivery of plasmid DNA, proteins, siRNA, and small molecules.1,2,3,4 Complexes of SAINT C-18 with plasmid DNA encoding pigment epithelium-derived factor (PEDF) inhibit corneal neovascularization induced by complexes of SAINT C-18 with plasmid DNA encoding FGF2, also known as basic FGF, in rats.[2]
References:
[1].van der Woude, I., Wagenaar, A., Meekel, A.A.P., et al.Novel pyridinium surfactants for efficient, nontoxic in vitro gene deliveryProc. Natl. Acad. Sci. USA94(4)1160-1165(1997).
[2].Kuo, C.-N., Yang, L.-C., Yang, C.-T., et al.Inhibition of corneal neovascularization with plasmid pigment epithelium-derived factor (p-PEDF) delivered by synthetic amphiphile INTeraction-18 (SAINT-18) vector in an experimental model of rat corneal angiogenesisExp. Eye Res.89(5)678-685(2009).
[3].van der Gun, B.T.F., Monami, A., Laarmann, S., et al.Serum insensitive, intranuclear protein delivery by the multipurpose cationic lipid SAINT-2J. Control Release123(3)228-238(2007).
[4].Adrian, J.E., Morselt, H.W., Süss, R., et al.Targeted SAINT-O-Somes for improved intracellular delivery of siRNA and cytotoxic drugs into endothelial cellsJ. Control Release144(3)341-349(2010).
| Cas No. | 187587-97-9 | SDF | |
| Synonyms | SAINT-2,SAINT-7,SAINT-18,Synthetic Amphiphile INTeraction C-18 | ||
| Formula | C43H78N•Cl | M.Wt | 644.5 |
| Solubility | Acetonitrile: Slightly soluble,Chloroform: Soluble | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.5516 mL | 7.758 mL | 15.5159 mL |
| 5 mM | 310.3 μL | 1.5516 mL | 3.1032 mL |
| 10 mM | 155.2 μL | 775.8 μL | 1.5516 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)