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Selamectin

Catalog No.GC32174

An anthelmintic antibiotic

Products are for research use only. Not for human use. We do not sell to patients.

Selamectin Chemical Structure

Cas No.: 220119-17-5

Size Price Stock Qty
10mM (in 1mL DMSO)
$79.00
In stock
5mg
$59.00
In stock
10mg
$95.00
In stock
25mg
$198.00
In stock
50mg
$324.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product has been cited by 1 publications

Product Documents

Quality Control & SDS

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Protocol

Animal experiment:

The cats are weighed on Days-2, 29 and 58 to calculate the dosing. Cats in group 1 (control group) remain untreated. On Day 0, the cats in group 3 are treated with fluralaner at the minimum recommending label dose of 40.0 mg per kg body weight. On Days 0, 30 and 60, the cats in group 2 are treated with the new spot-on formulation at the minimum recommending label dose of 1.0 mg/kg sarolaner and 6.0 mg/kg Selamectin. The cats are observed at different time points after treatment for possible adverse reactions to treatment. On Day 0, administration site observations are performed on all cats 30 min (±5 min), 3 h (±15 min) and 24 h (±1 h) and again on Days 3 and 5 after treatment[1].

References:

[1]. Thomas Geurden, et al. Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold Plus) versus fluralaner (Bravecto ) against induced infestations with Ixodes ricinus ticks on cats. Published online 2017 Jun 29.
[2]. Maria de Fátima Chicarino Varajao Moraes-da-Silva, et al. Selamectin for the prevention of canine Dirofilaria immitis infection: field efficacy in client-owned dogs in a high risk area. Published online 2016 Jul 22.

Background

Selamectin is an anthelminthic which can be used on dogs and cats.

Three monthly treatments with Selamectin/sarolaner provide high and consistent efficacy against I. ricinus for the entire duration of the study period. The percentage efficacy against I. ricinus is numerically higher in the Selemectin/sarolaner treating group than in the fluralaner-treating group on Days 56, 84 and 91[1]. All dogs are tested negative by both tests after receiving topical treatment with Selamectin monthly for 36 months[2].

[1]. Thomas Geurden, et al. Comparative efficacy of a new spot-on combination product containing selamectin and sarolaner (Stronghold®Plus) versus fluralaner (Bravecto®) against induced infestations with Ixodes ricinus ticks on cats. Published online 2017 Jun 29. [2]. Maria de Fátima Chicarino Varajao Moraes-da-Silva, et al. Selamectin for the prevention of canine Dirofilaria immitis infection: field efficacy in client-owned dogs in a high risk area. Published online 2016 Jul 22.

Chemical Properties

Cas No. 220119-17-5 SDF
Canonical SMILES O[C@@]12[C@@]3([H])/C(C(C)=C[C@@]1([H])C(O[C@]4([H])C[C@]5(O[C@@](C/C=C(C)/[C@@H](O[C@@]6([H])C[C@@H]([C@@H](O)[C@H](C)O6)OC)[C@@H](C)/C=C/C=C2\CO3)([H])C4)O[C@H](C7CCCCC7)[C@@H](C)CC5)=O)=N\O
Formula C43H63NO11 M.Wt 769.96
Solubility DMSO : 100 mg/mL (129.88 mM) Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

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1 mg 5 mg 10 mg
1 mM 1.2988 mL 6.4938 mL 12.9877 mL
5 mM 0.2598 mL 1.2988 mL 2.5975 mL
10 mM 0.1299 mL 0.6494 mL 1.2988 mL
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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

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Reviews

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Average Rating: 5 ★★★★★ (Based on Reviews and 14 reference(s) in Google Scholar.)

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