Senktide (trifluoroacetate salt) |
Catalog No.GC48981
One-Click Copy Product Info
|
A potent NK3 receptor agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Senktide is a potent, selective agonist of the neuromedin K3 (NK3) receptor (EC50 = 0.5-3 nM).1,2,3 It less potently agonizes the NK1 receptor (EC50 = 35 µM) and is without effect on the NK2 receptor.1,2,3 Senktide is used to study the action of the NK3 receptor in cells and in animals.4,5
1.Byk, G., Halle, D., Zeltser, I., et al.Synthesis and biological activity of NK-1 selective, N-backbone cyclic analogs of the C-terminal hexapeptide of substance PJ. Med. Chem39(16)3174-3178(1996) 2.Sarau, H.M., Griswold, D.E., Potts, W., et al.Nonpeptide tachykinin receptor antagonists: I. Pharmacological and pharmacokinetic characterization of SB 223412, a novel, potent and selective neurokinin-3 receptor antagonistJ. Pharmacol. Exp. Ther.281(3)1303-1311(1997) 3.Harrison, T., Korsgaard, M.P., Swain, C.J., et al.High affinity, selective neurokinin 2 and neurokinin 3 receptor antagonists from a common structural templateBioorg. Med. Chem. Lett.8(11)1343-1348(1998) 4.Thakar, A., Sylar, E., and Flynn, F.W.Activation of tachykinin, neurokinin 3 receptors affects chromatin structure and gene expression by means of histone acetylationPeptides38(2)282-290(2012) 5.Gaskins, G.T., Glanowska, K.M., and Moenter, S.M.Activation of neurokinin 3 receptors stimulates GnRH release in a location-dependent but kisspeptin-independent manner in adult miceEndocrinology154(11)3984-3989(2013)
| Cas No. | N/A | SDF | |
| Canonical SMILES | CN(C([C@@H](NC([C@@H](NC(CCC(O)=O)=O)CC(O)=O)=O)CC1=CC=CC=C1)=O)[C@H](C(NCC(N[C@H](C(N[C@@H](CCSC)C(N)=O)=O)CC(C)C)=O)=O)CC2=CC=CC=C2.FC(F)(C(O)=O)F | ||
| Formula | C40H55N7O11S·XCF3COOH | M.Wt | 842 |
| Solubility | DMSO: 5 mg/ml,PBS (pH 7.2): 2 mg/ml | Storage | -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 1.1876 mL | 5.9382 mL | 11.8765 mL |
| 5 mM | 237.5 μL | 1.1876 mL | 2.3753 mL |
| 10 mM | 118.8 μL | 593.8 μL | 1.1876 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >95.00% Appearance: A crystalline solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)