SI-W052 |
Catalog No.GC78589
One-Click Copy Product Info
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SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targetingmTORandTEX264.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2572552-60-2
Sample solution is provided at 25 µL, 10mM.
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SI-W052 is an orally active, brain-penetrant and selective small-molecule inhibitor targetingmTORandTEX264. SI-W052 activatesautophagyby inhibitingmTORphosphorylation and enhances TEX264 expression to promote ER turnover, suppressing LPS-induced release of inflammatory factors (TNF-α,IL-6). SI-W052 is promising for research of Alzheimer’s disease (AD)-associated neuroinflammation[1].
References:
[1].Wang Z, et al. Anti-Inflammatory Anthranilate Analogue Enhances Autophagy through mTOR and Promotes ER-Turnover through TEX264 during Alzheimer-Associated Neuroinflammation. ACS Chem Neurosci. 2022 Feb 2;13(3):406-422.
| Cas No. | 2572552-60-2 | SDF | |
| Formula | C20H19ClN2O5S | M.Wt | 434.89 |
| Solubility | Storage | -20°C | |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2994 mL | 11.4972 mL | 22.9943 mL |
| 5 mM | 459.9 μL | 2.2994 mL | 4.5989 mL |
| 10 mM | 229.9 μL | 1.1497 mL | 2.2994 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)