SMI-6860766 |
Catalog No.GC92425
One-Click Copy Product Info
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SMI-6860766 is an inhibitor of the protein-protein interaction between TNF receptor-associated factor 6 (TRAF6) and CD40.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 433234-16-3
Sample solution is provided at 25 µL, 10mM.
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SMI-6860766 is an inhibitor of the protein-protein interaction between TNF receptor-associated factor 6 (TRAF6) and CD40. It binds to TRAF1, TRAF2, TRAF3, and TRAF6 (Kds = 52, 30, 37, and 59 µM, respectively). SMI-6860766 inhibits LPS-induced increases in the levels of NF-κB in RAW 264.7 macrophages (IC50 = 0.3 µM). It inhibits anti-Cd40 antibody-induced increases in the levels of Il-1β and Il-6 in primary mouse bone marrow-derived macrophages (BMDMs; IC50s = 5.7 and 2.4 µM, respectively). SMI-6860766 (10 µmol/kg) increases survival in a mouse model of sepsis induced by cecal ligation and puncture. It decreases blood levels of glucose and adipose tissue levels of leukocytes, T helper cells (Ths), cytotoxic T cells, and M1 and M2 macrophages in a mouse model of diet-induced obesity (DIO) when administered at a dose of 10 µmol/kg per day.
| Cas No. | 433234-16-3 | SDF | |
| Chemical Name | 3-[(4-bromo-2-chlorophenyl)amino]-1-phenyl-2-propen-1-one | ||
| Canonical SMILES | O=C(C1=CC=CC=C1)C=CNC2=CC=C(Br)C=C2Cl | ||
| Formula | C15H11BrClNO | M.Wt | 336.613 |
| Solubility | Acetonitrile: Slightly soluble: 0.1-1 mg/ml | Storage | -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9708 mL | 14.8539 mL | 29.7077 mL |
| 5 mM | 594.2 μL | 2.9708 mL | 5.9415 mL |
| 10 mM | 297.1 μL | 1.4854 mL | 2.9708 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)