Somatostatin-28 (trifluoroacetate salt) |
| Catalog No.GC44916 |
Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation.
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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Somatostatin-28 is a cyclic neuropeptide hormone that has a role in endocrine regulation. It is a somatostatin (SST) receptor agonist that binds to SST1, SST2, SST3, SST4, and SST5 (IC50s = 0.60, 0.12, 0.22, 0.83, and 0.41 nM, respectively, in CCL39 cells expressing human recombinant receptors). It inhibits cAMP accumulation induced by forskolin in CCL39 cells expressing human recombinant SST1, SST2, SST3, SST4, and SST5 (EC50s = 5.13, 1.91, 6.46, 2.95, and 3.55 nM, respectively). Somatostatin-28 stimulates growth hormone (GH) release from primary porcine pituitary cells when used at a concentration of 1 fM. It inhibits acid secretion induced by gastrin I and IBMX in isolated rat gastric mucosa (EC50s = 27 and 252 nM, respectively). In vivo, somatostatin-28 dose-dependently increases basal and pentagastrin-induced gastric acid secretion in rats.
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