Sphinganine-d7 (d18:0) (Synonyms: Dihydrosphingosine-d7, D-erythro-Dihydrosphingosine-d7, Dihydro-D-erythro-Sphingosine-d7, Sphinganine-d7, D-erythro-Sphinganine-d7)

Sphinganine-d₇ (d18:0) is intended for use as an internal standard for the quantification of sphinganine (d18:0) by GC- or LC-MS. Sphinganine (d18:0) is a precursor to ceramide and sphingosine as well as a substrate of sphingosine kinases, which generate sphinganine-1-phosphate .¹ Sphinganine (d18:0) levels increase significantly in response to certain mycotoxins, including fumonisins, as well as in some cancers.^2,3,4

1.Smith, E.R., and Merrill, A.H., Jr.Differential roles of de novo sphingolipid biosynthesis and turnover in the 'Burst' of free sphingosine and sphinganine, and their 1-phosphates and N-acyl-derivatives, that occurs upon changing the medium of cells in cultureJ. Biol. Chem.270(32)18749-18758(1995) 2.Pruett, S.T., Bushnev, A., Hagedorn, K., et al.Biodiversity of sphingoid bases ("sphingosines") and related amino alcoholsJ. Lipid Res.49(8)1621-1639(2008) 3.Shephard, G.S., van der Westhuizen, L., and Sewram, V.Biomarkers of exposure to fumonisin mycotoxins: A reviewFood Addit. Contam.24(10)1196-1201(2007) 4.Yin, J., Miyazaki, K., Shaner, R.L., et al.Altered sphingolipid metabolism induced by tumor hypoxia - new vistas in glycolipid tumor markersFEBS Lett.584(9)1872-1878(2010)