STING Agonist 12b |
| Catalog No.GC48109 |
A STING agonist
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2411100-70-2
Sample solution is provided at 25 µL, 10mM.
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STING agonist 12b is an agonist of stimulator of interferon genes (STING).1 It binds to STING (Kd = 26.4 µM) and induces interferon reporter gene expression in cells expressing human or mouse STING (EC50s = 7.45 and 10.23 µM, respectively). STING agonist 12b (40 µM) induces expression of TNF-a, IL-6, IP-10, and IL-1b in THP-1 cells.
1.Hou, S., Lan, X.-j., Li, W., et al.Design, synthesis and biological evaluation of acridone analogues as novel STING receptor agonistsBioorg. Chem.95103556(2020)
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