STING Agonist 1a |
| Catalog No.GC48110 |
STING Agonist 1a (1a) is a specific stimulator of interferon genes (STING) agonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 652142-94-4
Sample solution is provided at 25 µL, 10mM.
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STING agonist 1a is an agonist of stimulator of interferon genes (STING).1 It induces expression of an IRF-inducible SEAP reporter gene in a cell-based assay (EC50 = 16.77 µM). STING agonist 1a (12.5-100 µM) induces expression of IFN-β, IL-6, and chemokine (C-X-C motif) ligand 10 (CXCL10) in THP-1 cells, an effect that can be reversed by STING knockout or the STING inhibitor H-151 .
1.Hou, H., Yang, R., Liu, X., et al.Discovery of triazoloquinoxaline as novel STING agonists via structure-based virtual screeningBioorg. Chem.100103958(2020)
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