Tapentadol-d3 (hydrochloride) (CRM)

Tapentadol-d₃ (CRM) is intended for use as an internal standard for the quantification of tapentadol . Tapentadol is an analytical reference material that is structurally categorized as an opioid. It is a µ-opioid receptor agonist (EC₅₀ = 1.8 µM) and inhibits noradrenaline reuptake in rat single locus coeruleus neurons.¹ It has been shown to suppress pain in animal models and in human clinical trials.^2,3 This product is intended for research and forensic applications.

1.Sadeghi, M., Tzschentke, T.M., and Christie, M.J.µ-Opioid receptor activation and noradrenaline transport inhibition by tapentadol in rat single locus coeruleus neuronsBritish Journal of Pharmacology172(2)460-468(2015) 2.Schiene, K., De Vry, J., and Tzschentke, T.M.Antinociceptive and antihyperalgesic effects of tapentadol in animal models of inflammatory painJournal of Pharmacology and Experimental Therapeutics339(2)537-544(2011) 3.Martini, C., van Velzen, M., Drewes, A., et al.A randomized controlled trial on the effect of Tapentadol and Morphine on conditioned pain modulation in healthy volunteersPLoS One10(6)(2016)