Taurohyodeoxycholic Acid MaxSpec® Standard (Synonyms: Taurine Hyodeoxycholate, THDCA)

Taurohyodeoxycholic acid (THDCA) is a taurine-conjugated form of the secondary bile acid hyodeoxycholic acid .¹ THDCA decreases the size and weight of human gallstones in vitro. It increases bile flow, biliary cholesterol secretion, and biliary lipid secretion in rats.² Co-administration of THDCA with taurochenodeoxycholic acid prevents TCDCA-induced hepatotoxicity, increasing bile flow as well as biliary acid and phospholipid secretion in rats.³ THDCA also reduces myeloperoxidase activity, expression of TNF-α and IL-6, and colonic damage in a mouse model of TNBS-induced ulcerative colitis.⁴

Taurohyodeoxycholic acid MaxSpec^® standard is a quantitative grade standard of taurohyodeoxycholic acid (sodium salt) that has been prepared specifically for mass spectrometry and related applications where quantitative reproducibility is required. The solution has been prepared gravimetrically and is supplied in a deactivated glass ampule sealed under argon. The concentration was verified by comparison to an independently prepared calibration standard. Verified concentration is provided on the certificate of analysis. This taurohyodeoxycholic acid MaxSpec^® standard is guaranteed to meet identity, purity, stability, and concentration specifications and is provided with a batch-specific certificate of analysis. Ongoing stability testing is performed to ensure the concentration remains accurate throughout the shelf life of the product. Note: The amount of solution added to the vial is in excess of the listed amount. Therefore, it is necessary to accurately measure volumes for preparation of calibration standards. Follow recommended storage and handling conditions to maintain product quality.

1.Angelico, M., Mogavero, L., Baiocchi, L., et al.Dissolution of human cholesterol gallstones in bile salt/lecithin mixtures: effect of bile salt hydrophobicity and various pHsScand. J. Gastroenterol.30(12)1178-1185(1995) 2.Angelico, M., Baiocchi, L., Nistri, A., et al.Effect of taurohyodeoxycholic acid, a hydrophilic bile salt, on bile salt and biliary lipid secretion in the ratDig. Dis. Sci.39(11)2389-2397(1994) 3.Roda, A., Piazza, F., Baraldini, M., et al.Taurohyodeoxycholic acid protects against taurochenodeoxycholic acid-induced cholestasis in the ratHepatology27(2)520-525(1998) 4.He, J., Liang, J., Zhu, S., et al.Protective effect of taurohyodeoxycholic acid from Pulvis Fellis Suis on trinitrobenzene sulfonic acid induced ulcerative colitis in miceEur. J. Pharmacol.670(1)229-235(2011)