Thiodiglycolic Acid-d4 (Synonyms: Dicarboxydimethyl sulfide-d4, Mercaptodiacetic Acid-d4, TDGA-d4, Thiodiacetic Acid-d4)

Thiodiglycolic acid-d₄ (TDGA-d₄) contains four deuterium atoms at the 2, 2, 2', and 2' positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.¹ Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.² Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.²

1.Navratil, T., Petr, M., Senholdova, Z., et al.Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substancesPhysiol.Res.56(1)113-122(2007) 2.Cheng, Y.J., Huang, Y.F., and Ma, Y.C.Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workersJ.Occup.Environ.Med.43(11)934-938(2001)