Thiodiglycolic Acid-d4 (Synonyms: Dicarboxydimethyl sulfide-d4, Mercaptodiacetic Acid-d4, TDGA-d4, Thiodiacetic Acid-d4) |
Catalog No.GC48166
One-Click Copy Product Info
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An internal standard for the quantification of thiodiglycolic acid
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 132090-51-8
Sample solution is provided at 25 µL, 10mM.
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Thiodiglycolic acid-d4 (TDGA-d4) contains four deuterium atoms at the 2, 2, 2', and 2' positions. It is intended for use as an internal standard for the quantification of TDGA by GC- or LC-mass spectrometry. TDGA is a product of interaction of the cysteine component of glutathione with two-carbon units released during catabolism. It is found in concentrations below 20 mg/l in urine of healthy individuals and elevated following ingestion of certain drugs.1 Determination of TDGA concentration in urine has been used to characterize the metabolism of substances participating in methionine synthesis in order to identify imbalances leading to hyperhomocystinuria.2 Additionally, because TDGA is used as raw material in the polymer industry, its detection in human urine has served as a biomarker for exposure to carcinogenic vapors such as vinylchloride monomer produced during polymer manufacture.2
1.Navratil, T., Petr, M., Senholdova, Z., et al.Diagnostic significance of urinary thiodiglycolic acid as a possible tool for studying the role of vitamins B12 and folates in the metabolism of thiolic substancesPhysiol.Res.56(1)113-122(2007) 2.Cheng, Y.J., Huang, Y.F., and Ma, Y.C.Urinary thiodiglycolic acid levels for vinyl chloride monomer-exposed polyvinyl chloride workersJ.Occup.Environ.Med.43(11)934-938(2001)
| Cas No. | 132090-51-8 | SDF | |
| Synonyms | Dicarboxydimethyl sulfide-d4, Mercaptodiacetic Acid-d4, TDGA-d4, Thiodiacetic Acid-d4 | ||
| Canonical SMILES | OC(C([2H])([2H])SC([2H])([2H])C(O)=O)=O | ||
| Formula | C4H2D4O4S | M.Wt | 154.2 |
| Solubility | DMF: 30 mg/ml,DMSO: 25 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 2 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 6.4851 mL | 32.4254 mL | 64.8508 mL |
| 5 mM | 1.297 mL | 6.4851 mL | 12.9702 mL |
| 10 mM | 648.5 μL | 3.2425 mL | 6.4851 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 10 reference(s) in Google Scholar.)