Tiotropium-d3 (bromide) |
| Catalog No.GC48182 |
An internal standard for the quantification of tiotropium
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1127226-56-5
Sample solution is provided at 25 µL, 10mM.
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Tiotropium-d3 is intended for use as an internal standard for the quantification of tiotropium by GC- or LC-MS. Tiotropium is an antagonist that binds to M1, M2, and M3 muscarinic acetylcholine receptors (Kds = 0.43, 0.54, and 0.69 nM, respectively, for human receptors).1 It decreases acetylcholine-induced contraction of isolated guinea pig trachea in a concentration-dependent manner. In vivo, tiotropium (1 g/L inhaled aerosol) confers complete protection against acetylcholine-induced bronchospasms in anesthetized dogs. Formulations containing tiotropium have been used in the treatment of chronic obstructive pulmonary disease (COPD).
1.Disse, B., Reichl, R., Speck, G., et al.Ba 679 BR, a novel long-acting anticholinergic bronchodilatorLife Sci.52(5-6)537-544(1993)
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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