TL4-12 |
| Catalog No.GC50295 |
Potent MAP4K2 (GCK) inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1620820-12-3
Sample solution is provided at 25 µL, 10mM.
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Potent MAP4K2 (GCK) inhibitor (IC50 = 37 nM). Exhibits >70-fold selectivity for MAP4K2 over TAK1 (IC50 = 2.7 μM for TAK1). Inhibits IL-1 and TGFβ-induced p38 MAPK phosphorylation, in vitro.
Tan et al (2015) Discovery of type II inhibitors of TGFβ-activated kinase 1 (TAK1) and mitogen-activated protein kinase kinase kinase kinase 2 (MAP4K2). J.Med.Chem. 58 183 PMID:25075558
Average Rating: 5 (Based on Reviews and 12 reference(s) in Google Scholar.)
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