UM-259 hydrochloride |
Catalog No.GC79431
One-Click Copy Product Info
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UM-259 hydrochloride is a STING inhibitor with activity against both murine and human STING (including the STING R232 mutant).
Products are for research use only. Not for human use. We do not sell to patients.
Sample solution is provided at 25 µL, 10mM.
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In Vitro, UM-259 hydrochloride (0.08-40 μM; 1 h + 24 h; diABZI) inhibits STING-dependent signaling pathways in THP1-Dual KI-hSTING-R232 cells, with an EC50 of 1.50 μM[1]. UM-259 hydrochloride (0.2-5 μM; 1 h + 2 h; diABZI) dose-dependently inhibits diABZI-induced IFNβ and IL6 gene expression in iBMDM, and exhibits superior potency to LB244 at a concentration of 5 μM[1]. UM-259 hydrochloride (0.2-5 μM; 1 h +24 h; diABZI) dose-dependently inhibits diABZI-induced IFNβ secretion in iBMDMs, and its efficacy at 5 μM is superior to that of LB244[1]. UM-259 hydrochloride (2.5 μM; 1 h + 16 h; diABZI) inhibits diABZI-induced IFNβ secretion in primary human CD14+ monocytes[1]. UM-259 hydrochloride (5 μM; 1 h+0-120 min; diABZI) inhibits diABZI-induced phosphorylation of TBK1 and IRF3 in wild-type bone marrow-derived macrophages (BMDMs)[1]. UM-259 hydrochloride (5 μM; 1 h+30 min; diABZI) blocks diABZI-induced STING oligomerization in wild-type bone marrow-derived macrophages (BMDMs)[1]. UM-259 hydrochloride (0.2-5 μM; 24 h) exhibits only limited cytotoxicity against iBMDMs[1].
References:
[1]. Barasa L, et al. Nitrofuran-Based STING Inhibitors. ACS Omega. 2025;10(36):41693-41706. Published 2025 Sep 4.
| Cas No. | SDF | ||
| Formula | C27H22ClF2N7O5 | M.Wt | 597.96 |
| Solubility | DMSO: 100 mg/mL (167.24 mM; Need ultrasonic) | Storage | Store at -20°C |
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.6724 mL | 8.3618 mL | 16.7235 mL |
| 5 mM | 334.5 μL | 1.6724 mL | 3.3447 mL |
| 10 mM | 167.2 μL | 836.2 μL | 1.6724 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 30 reference(s) in Google Scholar.)