Valproic Acid-d4 (sodium salt) (Synonyms: 2-Propylvaleric Acid-d4, Valproate-d4, VPA-d4) |
Catalog No.GC48240
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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Valproic acid-d4 (sodium salt) is intended for use as an internal standard for the quantification of valproic acid by GC- or LC-MS. Valproic acid is an analog of the natural fatty acid valeric acid that inhibits class I histone deacetylases (HDACs) with an IC50 value of approximately 2 mM.1 It decreases the number of axon branches in sensory neurons isolated from newborn rat dorsal root ganglia, an effect that is reversed by inositol-1,4,5-trisphosphate (1,4,5-IP3).2 In vivo, valproic acid inhibits amyloid-β deposition and neuritic plaque formation and decreases escape latency in the Morris water maze, indicating improved memory performance, in the APP23 transgenic mouse model of Alzheimer's disease.3 Valproic acid has anticonvulsant activity in the pentylenetetrazol seizure threshold test in mice (ED50 = 0.71 mmol/kg) but induces neurotoxicity when administered at doses greater than or equal to 1.2 mmol/kg.4 Formulations containing valproic acid have been used to treat bipolar disorder and various seizure disorders.
1.GÖttlicher, M., Minucci, S., Zhu, P., et al.Valproic acid defines a novel class of HDAC inhibitors inducing differentiation of transformed cellsEMBO J.20(24)6969-6978(2001) 2.Williams, R.S.B., Cheng, L., Mudge, A.W., et al.A common mechanism of action for three mood-stabilizing drugsNature417(6886)292-295(2002) 3.Qing, H., He, G., Ly, P.T., et al.Valproic acid inhibits Aβ production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse modelsJ. Exp. Med.205(12)2781-2789(2008) 4.Elmazar, M.M., Hauck, R.S., and Nau, H.Anticonvulsant and neurotoxic activities of twelve analogues of valproic acidJ. Pharm. Sci.82(12)1255-1258(1993)
| Cas No. | N/A | SDF | |
| Synonyms | 2-Propylvaleric Acid-d4, Valproate-d4, VPA-d4 | ||
| Canonical SMILES | CCC([2H])([2H])C(C([2H])([2H])CC)C([O-])=O.[Na+] | ||
| Formula | C8H11D4O2.Na | M.Wt | 170.2 |
| Solubility | DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 30 mg/ml,PBS (pH 7.2): 10 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 5.8754 mL | 29.3772 mL | 58.7544 mL |
| 5 mM | 1.1751 mL | 5.8754 mL | 11.7509 mL |
| 10 mM | 587.5 μL | 2.9377 mL | 5.8754 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)