Virginiamycin Complex (Synonyms: Mikamycin,RP 7293,Stapyocine,Streptogramin) |
| Catalog No.GC17058 |
a complex contains two streptogramin antibiotics
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 11006-76-1
Sample solution is provided at 25 µL, 10mM.
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Virginiamycin Complex is a a complex containing two streptogramin antibiotics.
Virginiamycin complex contains two streptogramin antibiotics, virginiamycin M1 (75%) and virginiamycin S1 (25%), produced by S. virginiae.
In vitro: Previous study found that the M1 and S1 components of virginiamycin (VM and VS) could inhibit protein synthesis in bacteria--reversibly when a single component was present and irreversibly when both were present. In cell-free systems, each factor bound to the large ribosomal subunit, and the affinity of ribosomes for VS was enhanced in the presence of VM. In addition, the binding of labeled VM to ribosomes yielded particles unable to perform poly(U)-directed polyphenylalanine synthesis. Moreover, the association constant for the binding of VS to these particles was equal to that incubated with a mixture of VM and VS [1].
In vivo: A radiochemical method was developed to estimate cholyltaurine hydrolase potentials and rates of cholyltaurine hydrolysis in chicken intestinal homogenates. This method was used to monitor the effects of antibiotic feed additives on cholyltaurine hydrolase activity. Results showed that virginiamycin could improve the rate of weight gain and feed conversion and decrease cholyltaurine hydrolase activity in ileal homogenates relative [2].
Clinical trial: So far, no clinical study has been conducted.
References:
1. Parfait, R., and Cocito, C. Lasting damage to bacterial ribosomes by reversibly bound virginiamycin M. Proceedings of the National Academy of Sciences of the United States of America 77(9), 5492-5496 (1980).
2. Feighner, S.D., and Dashkevicz, M.P. Subtherapeutic levels of antibiotics in poultry feeds and their effects on weight gain, feed efficiency, and bacterial cholyltaurine hydrolase activity. Applied and Environmental Microbiology 53(2), 331-336 (1987).
| Cas No. | 11006-76-1 | SDF | |
| Synonyms | Mikamycin,RP 7293,Stapyocine,Streptogramin | ||
| Chemical Name | N-((6R,9S,10R,13S,15aS,22S,24aS)-22-benzyl-6-ethyl-10,23-dimethyl-5,8,12,15,17,21,24-heptaoxo-13-phenyldocosahydro-12H-pyrido[2,1-f]pyrrolo[2,1-l][1]oxa[4,7,10,13,16]pentaazacyclononadecin-9-yl)-3-hydroxypicolinamide compound with (12Z,6R,7R,8E,13Z,15E,17 | ||
| Canonical SMILES | O=C1CCN(C([C@@H](N(C)C([C@@]23[H])=O)CC4=CC=CC=C4)=O)[C@@](C(N[C@@H](C5=CC=CC=C5)C(O[C@H](C)[C@H](NC(C6=NC=CC=C6O)=O)C(N[C@H](CC)C(N2CCC3)=O)=O)=O)=O)([H])C1.O=C(/C=C/[C@@H](C)[C@@H](C(C)C)OC(C7=CCCN7C(C8=COC(C9)=N8)=O)=O)NC/C=C\C(C)=C\[C@@H](O)CC9=O | ||
| Formula | C43H49N7O10 • C28H35N3O10 | M.Wt | 1396.6 |
| Solubility | ≤15mg/ml in DMSO;30mg/ml in dimethyl formamide | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
||
| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 0.716 mL | 3.5801 mL | 7.1602 mL |
| 5 mM | 0.1432 mL | 0.716 mL | 1.432 mL |
| 10 mM | 0.0716 mL | 0.358 mL | 0.716 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 36 reference(s) in Google Scholar.)
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