Guanylate Cyclase
GC (guanylyl cyclaese) converts GTP into cGMP and pyrophosphate. sGC (soluble GC) is a nitric oxide receptor and pGC (transmembrance GC) is a natriiuritic peptide receptor. Its major functions include cell hyperplasia,hypertrophy, cell differentiation and tumor progression etc.
Products for Guanylate Cyclase
- Cat.No. Product Name Information
- GC34045 (4-Acetamidocyclohexyl) nitrate (BM121307) (4-Acetamidocyclohexyl) nitrate (BM121307) (BM121307) is a guanylate cyclase activator.
- GC64490 (Rac)-MGV354 (Rac)-MGV354 is the racemate of MGV354.
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GC11361
Ataciguat
activator of the oxidized (heme-free) form of soluble guanylate cyclase (sGC)
- GC10192 BAY 41-2272 Activator of soluble guanylyl cyclase (sGC)
- GC11426 BAY 41-8543 heme-dependent stimulator of soluble guanylate cyclase (sGC)
- GC65051 BAY 60-2770 BAY 60-2770 is a potent, selective, and orally active soluble guanylyl cyclase (sGC) activator.
- GC10962 Cinaciguat An activator of sGC
- GC19459 Cinaciguat hydrochloride Cinaciguat hydrochloride is a potent soluble guanylate cyclase (GC) activator with EC50 of 15 nM in platelets.
- GC61604 Guanylin(human) TFA Guanylin(human) TFA, a 15-amino acid peptide, is an endogenous intestinal guanylate cyclase activator.
- GC30016 Linaclotide A peptide agonist of the guanylate cyclase C receptor
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GC13857
LY83583
inhibitor of soluble guanylate cyclase and of cGMP production
- GC30051 Methylene Blue (Basic Blue 9) Methylene blue (Basic Blue 9) is a guanylyl cyclase (sGC), monoamine oxidase A (MAO-A) and NO synthase (NOS) inhibitor.
- GC39603 Methylene blue trihydrate Methylene blue trihydrate (C.
- GC62616 MGV354 MGV354 is a soluble guanylate cyclase (sGC) activator with EC50s of <0.5 nM, and 5 nM in CHO and GTM-3 E cells, respectively.
- GC63294 MM 419447 MM 419447, a linaclotide metabolite, is a guanylate cyclase-C agonist.
- GC32493 Nelociguat (BAY60-4552) Nelociguat (BAY60-4552) (BAY60-4552) is a nitric oxide sensitive soluble guanylate cyclase stimulator.
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GC16975
NS 2028
soluble guanylyl cyclase (sGC) inhibitor
- GC36801 Olinciguat Olinciguat (IW-1701) is an oral guanylate cyclase (sGC) stimulator with concentration-dependent stimulation of sGC in purified rat and human enzyme assays and a whole cell assay.
- GC33898 Plecanatide acetate Plecanatide acetate, an analogue of Uroguanylin, is an orally active guanylate cyclase-C (GC-C) receptor agonist.
- GC65449 Praliciguat Praliciguat (IW-1973) is a potent and orally active soluble guanylate cyclase stimulator, enhances NO signaling, acts as a vasodilator.
- GC12887 Riociguat A stimulator of soluble guanylate cyclase
- GC65192 Runcaciguat Runcaciguat is an orally active stimulator of soluble guanylate cyclase, and is used in the research of cardiovascular and renal diseases combined with selective partial adenosine A1 receptor agonists.
- GC32472 Vericiguat (BAY1021189) Vericiguat (BAY1021189) (BAY1021189) is a potent, orally available and soluble guanylate cyclase stimulator.
- GC16406 YC 1 YC 1 binds to the β subunit of soluble guanylyl cyclase(sGC) with Kd of 0.6-1.1 μM in the presence of CO.
- GC65182 Zagociguat Zagociguat is the stimulator of soluble guanylate cyclase.