Enterovirus
Human rhinoviruses (HRVs) and enteroviruses (HEVs) belong to the Picornaviridae family and are prominent causes of respiratory disease. They share identical genomic organization and high sequence homology. Their genome is divided into three sections: a 5’untranslated region (5’UTR), an open reading frame of the polyprotein that codes for all four capsid proteins (VP1-4) and the non-structural genes, and a 3’untranslated region.
Enteroviruses are members of the picornavirus family, a large and diverse group of small RNA viruses. According to the present classification, the enterovirus genus comprises the following species: poliovirus, human enterovirus A (HEV-A) (coxackie A viruses and enterovirus 71), HEV-B (coxsackie B viruses, echoviruses, coxsackie A9 virus, and enteroviruses 69 and 73), HEV-C (coxsackie A viruses), HEV-D (enteroviruses 68 and 70), and at least three animal enterovirus species (bovine, simian, and porcine enteroviruses). They all contain a genome of approximately 7,500 bases and positive [(+)]-strand polarity. After infection of the host cell, the genome is translated in a cap-independent manner into a single polyprotein, which is subsequently processed by virus-encoded proteases into the structural capsid proteins and the nonstructural proteins, which are mainly involved in the replication of the virus.
Targets for Enterovirus
Products for Enterovirus
- Cat.No. Product Name Information
- GC39353 Brilliant Black BN A sulfonated azo dye with antiviral activity
- GC60099 Carbocisteine Carbocisteine, a mucolytic agent, can be used for the research of chronic obstructive pulmonary disease (COPD).
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GC41462
cis-Resveratrol
Resveratrol is a potent phenolic antioxidant found in grapes, red wine, and various berries that also has antiproliferative and anti-inflammatory activity.
- GC64636 DMA-135 hydrochloride DMA-135 hydrochloride inhibits enterovirus 71 (EV71) IRES-dependent translation and replication.
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GC18620
EIDD-1931
A ribonucleoside analog with antiviral activity
- GC38050 Hederasaponin B A triterpene saponin with antiviral and antioxidant activities
- GC39097 Mosloflavone Mosloflavone is a flavonoid isolated from Scutellaria baicalensis Georgi with ?anti-EV71 activity.
- GC61956 NHC-diphosphate NHC-diphosphate is an active phosphorylated?intracellular metabolite?of β-d-N4-Hydroxycytidine (NHC) as a diphosphate form.
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GC61130
NHC-triphosphate
NHC-triphosphate is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.
- GC61961 NHC-triphosphate tetrasodium NHC-triphosphate tetrasodium is an active phosphorylated intracellular metabolite of β-d-N4-Hydroxycytidine (NHC) as a triphosphate form.
- GC45990 Norwogonin A polyhydroxy flavone with diverse biological activities
- GC17737 PD 169316 P38 MAPK inhibitor
- GC19296 Pirodavir Pirodavir is a potent, broad-spectrum picornavirus inhibitor, and is highly active against both group A and group B rhinovirus serotypes.
- GC32067 Pleconaril (VP 63843) Pleconaril (VP 63843) is a capsid inhibitor used previously to treat enterovirus infections.
- GC32120 Pocapavir (SCH-48973) Pocapavir (SCH-48973) (SCH-48973) is an orally active capsid inhibitor.
- GC39066 Prunin A flavonoid glycoside with diverse biological activities
- GC50441 Rupintrivir Potent and selective irreversible human rhinovirus 3C protease inhibitor
- GC61359 TTP-8307 TTP-8307 is a potent inhibitor of the replication of several rhino- and enteroviruses.
- GC48241 Vapendavir A capsid-binding antiviral agent
- GC63291 WIN 54954 WIN 54954 is an orally active and broad-spectrum antipicornavirus agent.