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Rupintrivir (Synonyms: AG7088)

Catalog No.GC50441

Potent and selective irreversible human rhinovirus 3C protease inhibitor

Products are for research use only. Not for human use. We do not sell to patients.

Rupintrivir Chemical Structure

Cas No.: 223537-30-2

Size Price Stock Qty
1 mg
$117.00
In stock
5 mg
$266.00
In stock

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Sample solution is provided at 25 µL, 10mM.

Product Documents

Quality Control & SDS

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Background

Potent and selective irreversible human rhinovirus (HRV) 3C protease inhibitor (EC50 = 5 nM). Exhibits no significant inhibition against a variety of serine and cysteine proteases. Inhibits replication of a panel of 48 different HRV serotypes in H1-HeLA and MRC-5 cell protection assays. products are for biomedical research use only. They are not intended for human or veterinary use.

Patick et al (1999) In vitro antiviral activity of AG7088, a potent inhibitor of human rhinovirus 3C protease. Antimicrob.Agents Chemother. 43 2444 PMID:10508022 |Dragovich et al (1999) Structure-based design, synthesis, and biological evaluation of irreversible human rhinovirus 3C protease inhibitors. 3. Structure-activity studies of ketomethylene-containing peptidomimetics. J.Med.Chem. 42 1203 PMID:10197964

Chemical Properties

Cas No. 223537-30-2 SDF
Synonyms AG7088
Canonical SMILES O=C(C1=NOC(C)=C1)N[C@@H](C(C)C)C(C[C@@H](CC2=CC=C(F)C=C2)C(N[C@H](/C=C/C(OCC)=O)C[C@@H]3CCNC3=O)=O)=O
Formula C31H39FN4O7 M.Wt 598.66
Solubility Soluble in DMSO Storage Store at -20°C
General tips Please select the appropriate solvent to prepare the stock solution according to the solubility of the product in different solvents; once the solution is prepared, please store it in separate packages to avoid product failure caused by repeated freezing and thawing.Storage method and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored at -20°C, please use it within 1 month.
To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time.
Shipping Condition Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request.

Complete Stock Solution Preparation Table

Prepare stock solution
1 mg 5 mg 10 mg
1 mM 1.6704 mL 8.352 mL 16.704 mL
5 mM 0.3341 mL 1.6704 mL 3.3408 mL
10 mM 0.167 mL 0.8352 mL 1.6704 mL
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In vivo Formulation Calculator (Clear solution)

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )

Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.

Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.

Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.

Reviews

Review for Rupintrivir

Average Rating: 5 ★★★★★ (Based on Reviews and 11 reference(s) in Google Scholar.)

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