17-Hydroxyprogesterone (Synonyms: NSC 15468, 17-OHP, 17-hydroxy Progesterone) |
| Catalog No.GC17475 |
An endogenous progestogen and chemical intermediate
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 68-96-2
Sample solution is provided at 25 µL, 10mM.
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17-Hydroxyprogesterone, an endogenous progestogen and chemical intermediate in the biosynthesis of other steroid hormones, is also the parent compound of various progestins derivatives.
In vitro: 17-Hydroxyprogesterone was found to be an agonist of the progesterone receptor (PR), which was similarly to progesterone. In addition, 17-hydroxyprogesterone was also an antagonist of the mineralocorticoid receptor (MR) as well as a partial agonist of the glucocorticoid receptor (GR), with very low potency (EC50>100-fold less relative to cortisol), which was also similarly to progesterone [1].
In vivo: Findings from a previous rat in vivo study demonstrated that even if modest, lowering blood pressure with 17-hydroxyprogesterone could be a viable treatment selection for blocking inflammation and uterine artery vasoconstriction, whereas improving litter size [2].
Clinical trial: Clinically, 17-hydroxyprogesterone has been evaluated in newborn screening programs as the biomarker to detect the rare but potentially fatal inherited disease, such as congenital adrenal hyperplasia. Results showed that the respiratory distress syndrome was related with higher 17-hydroxyprogesterone level. In addition, higher 17-hydroxyprogesterone and false positives were found to be significantly related with lower gestational age and birth weight, which was the same as that previously reported [3].
References:
[1] Barbara J. Attardi, et al. Comparison of progesterone and glucocorticoid receptor binding and stimulation of gene expression by progesterone, 17-alpha hydroxyprogesterone caproate (17-OHPC), and related progestins. Am J Obstet Gynecol. 2007 Dec; 197(6): 599.e1–599.e7.
[2] Lorena M. Amaral, et al. 17- hydroxyprogesterone caproate significantly improves clinical characteristics of preeclampsia in the Rupp rat model. Hypertension. 2015 Jan; 65(1): 225–231.
[3] Ryckman KK,Cook DE,Berberich SL,Shchelochkov OA,Berends SK,Busch T,Dagle JM,Murray JC. Replication of clinical associations with 17-hydroxyprogesterone in preterm newborns. J Pediatr Endocrinol Metab. 2012;25(3-4):301-5.
| Cas No. | 68-96-2 | SDF | |
| Synonyms | NSC 15468, 17-OHP, 17-hydroxy Progesterone | ||
| Chemical Name | (8R,9S,10R,13S,14S,17R)-17-acetyl-17-hydroxy-10,13-dimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3(2H)-one | ||
| Canonical SMILES | CC([C@@]1(O)CC[C@@]2([H])[C@]([C@]3([H])CC[C@@]21C)([H])CCC4=CC(CC[C@@]43C)=O)=O | ||
| Formula | C21H30O3 | M.Wt | 330.46 |
| Solubility | ≥ 31.6 mg/mL in DMSO, ≥ 16 mg/mL in EtOH with gentle warming | Storage | Store at 4°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.0261 mL | 15.1304 mL | 30.2608 mL |
| 5 mM | 0.6052 mL | 3.0261 mL | 6.0522 mL |
| 10 mM | 0.3026 mL | 1.513 mL | 3.0261 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
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- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 38 reference(s) in Google Scholar.)
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