5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine |
| Catalog No.GC46682 |
An mPGES-1 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
![5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Chemical Structure](/media/struct/GC4/GC46682.png "5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Chemical Structure")
Cas No.: 2253745-78-5
Sample solution is provided at 25 µL, 10mM.
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5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).1 It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)
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