5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine |
Catalog No.GC46682
One-Click Copy Product Info
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An mPGES-1 inhibitor
Products are for research use only. Not for human use. We do not sell to patients.
![5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Chemical Structure](/media/struct/GC4/GC46682.png "5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine Chemical Structure")
Cas No.: 2253745-78-5
Sample solution is provided at 25 µL, 10mM.
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5-Butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine is an inhibitor of microsomal prostaglandin E synthase-1 (mPGES-1; IC50s = 66 and 2,730 nM for the human and mouse enzymes, respectively).1 It is selective for mPGES-1 over COX-1 but does inhibit COX-2 at 20 µM. It also inhibits LPS-induced prostaglandin E2 production in mouse peritoneal cells (IC50 = 12 nM). In vivo, 5-butyl-4-[2,3-difluoro-4-(phenylmethoxy)phenyl]-6-phenyl-2-pyrimidinamine (25 mg/kg) reduces carrageenan-induced paw edema in rats.
1.Kal?ic, F., Kolman, V., Ajani, H., et al.Polysubstituted pyrimidines as mPGES-1 inhibitors: Discovery of potent inhibitors of PGE2 production with strong anti-inflammatory effects in carrageenan-induced rat paw edemaChemMedChem15(15)1398-1407(2020)
| Cas No. | 2253745-78-5 | SDF | |
| Canonical SMILES | NC1=NC(C2=CC=C(OCC3=CC=CC=C3)C(F)=C2F)=C(CCCC)C(C4=CC=CC=C4)=N1 | ||
| Formula | C27H25F2N3O | M.Wt | 445.5 |
| Solubility | Chloroform: 10 mg/ml,Ethanol: 10 mg/ml,Methyl Acetate: 1 mg/ml | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.2447 mL | 11.2233 mL | 22.4467 mL |
| 5 mM | 448.9 μL | 2.2447 mL | 4.4893 mL |
| 10 mM | 224.5 μL | 1.1223 mL | 2.2447 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00% Appearance: A solution in methyl acetate
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)