Cyclooxygenase
Products for Cyclooxygenase
- Cat.No. Product Name Information
- GC41431 δ12-Prostaglandin D2 Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.
- GC41109 δ12-Prostaglandin J2 δ12-Prostaglandin J2 (δ12-PGJ2) is a cyclopentenone prostaglandin (PG) with anti-proliferative effect on various tumor cell growth. δ12-Prostaglandin J2, a naturally occurring dehydration product of prostaglandin D2, is able to induce apoptosis in HeLa cells via caspase activation.
- GC41476 δ17-6-keto Prostaglandin F1α δ17-6-keto Prostaglandin F1α (δ17-6-keto PGF1α) is a cyclooxygenase (COX) product of eicosapentaenoic acid (EPA) in various tissues such as seminal vesicles, lung, Polymorphonuclear leukocytes, and ocular tissues.
- GC49515 (±)-Ibuprofen-d3 (sodium salt) An internal standard for the quantification of (±)-ibuprofen
- GC45278 (±)-Ketoprofen-d3
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GC40270
(±)5(6)-DiHET
5(6)-DiHET is a fully racemic version of the enantiomeric forms biosynthesized from 5(6)-EET by epoxide hydrolases.
- GC40272 (±)8(9)-DiHET Epoxide hydrolases convert the EETs into vicinal diols, with the concurrent loss of much of their biological activity.
- GC40281 (+)-15-epi Cloprostenol Cloprostenol is a synthetic prostaglandin F2α (PGF2α) analog and a potent FP receptor agonist.
- GC40282 (+)-5-trans Cloprostenol Cloprostenol is a synthetic derivative of prostaglandin F2α that is used in veterinary medicine as a luteolytic agent for the induction of estrus and in the treatment of reproductive disorders in cattle, swine, and horses.
- GC45260 (+)-Cloprostenol isopropyl ester (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α).
- GC45262 (+)-Cloprostenol methyl ester (+)-Cloprostenol is a synthetic analog of prostaglandin F2α (PGF2α).
- GC46245 (-)-G-Lactone A bicyclic γ-lactone
- GC48508 (4-Carboxybutyl-d4)triphenylphosphonium (bromide) An internal standard for the quantification of (4-carboxybutyl)triphenylphosphonium
- GC40716 (R)-Butaprost Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype.
- GC41714 (R)-Butaprost (free acid) Butaprost is a structural analog of prostaglandin E2 (PGE2) with good selectivity for the EP2 receptor subtype.
- GC41723 (S)-(-)-1,1'-Bi-2-naphthol S-BINOL is a chiral auxiliary for asymmetric ketone reduction, in particular 15-keto prostaglandin intermediates to 15(S)-alcohols.
- GC41735 (S)-AL 8810 AL 8810 is an 11β-fluoro analog of PGF2α which acts as a potent and selective antagonist at the FP receptor.
- GC49179 (S)-O-Desmethyl Naproxen A metabolite of (S)-naproxen
- GC45948 1,2,3-Trilinoelaidoyl-rac-glycerol A triacylglycerol
- GC41761 1-(6-Methoxy-2-naphthyl)ethanol 1-(6-Methoxy-2-naphthyl)ethanol is a potential impurity in commercial preparations of naproxen.
- GC49366 1-Salicylate Glucuronide A metabolite of salicylic acid and aspirin
- GC40577 11β-13,14-dihydro-15-keto Prostaglandin F2α 11β-13,14-dihydro-15-keto Prostaglandin F2α (11β-13,14-dihydro-15-keto PGF2α) is a metabolite of Prostaglandin D2 (PGD2) in the 15-hydroxy PGDH pathway.
- GC41243 11β-Misoprostol Misoprostol is a widely sold analog of prostaglandin E1 (PGE1) which has potent but relatively non-selective agonist activity with respect to the prostanoid EP receptor subgroup.
- GC41410 11β-Prostaglandin E2 11β-Prostaglandin E2 (11β-Dinoprostone), a Prostanoid derivative, inhibits [3H]PGE2 binding to hypothalamic membranes in the rat with a Ki of 53.3 nM.
- GC41432 11β-Prostaglandin F1β 11β-PGF1β is the stereoisomer of PGF1α with both C-9 and C-11 hydroxyls inverted.
- GC41404 11β-Prostaglandin F2α Ethanolamide 11β-Prostaglandin F2α ethanolamide (11β-PGF2α-EA) is the theoretical hepatic metabolite of PGD2-EA, produced during COX-2 metabolism of the endogenous cannabinoid AEA which is found in brain, liver, and other mammalian tissues.
- GC46412 11β-Prostaglandin F2α-d4 An internal standard for the quantification of 11β-PGF F2α
- GC40422 11(R)-HEDE 11(R)-HEDE is produced from 11Z,14Z-eicosadienoic acid by COX in a lipoxygenase-type reaction.
- GC18660 11-dehydro Thromboxane B2 Thromboxane B2 (TXB2) is released in substantial quantities from aggregating platelets and metabolized during circulation to 11-dehydro TXB2 and 2,3-dinor TXB2.
- GC46408 11-dehydro Thromboxane B2-d4 An internal standard for the quantification of 11dehydro thromboxane B2
- GC41877 11-dehydro Thromboxane B3 11-dehydro TXB3 is a urinary metabolite of TXA3 in humans with enhanced dietary intake of EPA.
- GC18634 11-deoxy Prostaglandin E1 11-deoxy Prostaglandin E1 (11-deoxy PGE1) is a synthetic analog of PGE1.
- GC41121 11-deoxy Prostaglandin E2 11-deoxy Prostaglandin E2 (11-deoxy PGE2) is a stable, synthetic analog of PGE2.
- GC41401 11-deoxy Prostaglandin F1α 11-deoxy PGF1α is a synthetic analog of PGF1α.
- GC41402 11-deoxy Prostaglandin F1β 11-deoxy PGF1β is a synthetic analog of PGF1β.
- GC40274 11-deoxy Prostaglandin F2α 11-deoxy PGF2α is a synthetic analog of PGF2α.
- GC40275 11-deoxy Prostaglandin F2β 11-deoxy Prostaglandin F2β (11-deoxy PGF2β) is an analog of PGF2β.
- GC40335 11-deoxy-11-methylene Prostaglandin D2 Prostaglandin D2 is one of the five primary enzymatic prostaglandins derived directly from PGH2.
- GC41879 11-deoxy-11-methylene-15-keto Prostaglandin D2 Prostaglandin D2 (PGD2) is one of the five primary enzymatic prostaglandins derived directly from PGH2.
- GC40390 11-deoxy-16,16-dimethyl Prostaglandin E2 11-deoxy-16,16-dimethyl PGE2 is a stable synthetic analog of PGE2.
- GC41880 11-keto Fluprostenol 11-keto Fluprostenol is an analog of prostaglandin D2 (PGD2) with structural modifications intended to give it a prolonged half-life and greater potency.
- GC18617 11β-Prostaglandin E1 11β-Prostaglandin E1 (11β-PGE1) is an epimerized form of PGE1 at the C-11 position.
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GC18637
11β-Prostaglandin F2α
11β-Prostaglandin F2α (11β-PGF2α) is the primary plasma metabolite of PGD2 in vivo.
- GC19462 13(R)-HODE 13(R)-HODE is the opposite enantiomer of the 13(S)-HODE produced when linoleic acid is incubated with soybean lipoxygenase.
- GC46420 13(S)-HODE-d4 An internal standard for the quantification of 13-HODE
- GC40745 13,14-dehydro-15-cyclohexyl Carbaprostacyclin 13,14-dehydro-15-cyclohexyl Carbaprostacyclin is a chemically stable analog of PGI2.
- GC41433 13,14-dihydro Prostaglandin E1 13,14-dihydro Prostaglandin E1 (13,14-dihydro PGE1) is a biologically active metabolite of PGE1 with comparable potency to the parent compound.
- GC41902 13,14-dihydro Prostaglandin F1α 13,14-dihydro PGF1α is a potential metabolite of PGF1α.
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GC41434
13,14-dihydro Prostaglandin F2α
13,14-dihydro Prostaglandin F2α (13,14-dihydro PGF2α) is the analog of PGF2α which has no unsaturation in the lower side chain.
- GC41435 13,14-dihydro-15(R)-Prostaglandin E1 13,14-dihydro-15(R)-Prostaglandin E1 (13,14-dihydro-15(R)-PGE1) is an analog of 13,14-dihydro-PGE1 , which has the hydroxyl group at C-15 in the unnatural R configuration.
- GC41097 13,14-dihydro-15-keto Prostaglandin A2 PGE2 is metabolized rapidly to 13,14-dihydro-15-keto PGE2, which is present in the plasma of humans and other mammals.
- GC40578 13,14-dihydro-15-keto Prostaglandin D1 Prostaglandin D1 (PGD1) is the theoretical D-series metabolite of dihomo-γ-linolenic acid (DGLA), but to date it has not been isolated as a natural product.
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GC41411
13,14-dihydro-15-keto Prostaglandin D2
13,14-dihydro-15-keto Prostaglandin D2 (13,14-dihydro-15-keto PGD2) is a metabolite of PGD2 which is formed through the 15-hydroxy PGDH pathway.
- GC18783 13,14-dihydro-15-keto Prostaglandin E1 13,14-dihydro-15-keto Prostaglandin E1 (PGE1) is a metabolite of PGE1 with much reduced biological activity.
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GC41413
13,14-dihydro-15-keto Prostaglandin E2
13,14-dihydro-15-keto Prostaglandin E2 (13,14-dihydro-15-keto PGE2) is the primary metabolite of PGE2 in plasma.
- GC41436 13,14-dihydro-15-keto Prostaglandin F1α 13,14-dihydro-15-keto Prostaglandin F1α (13,14-dihydro-15-keto PGF1α) is a metabolite of PGF1α that has been reported in the rat stomach.
- GC40579 13,14-dihydro-15-keto Prostaglandin F2α 13,14-dihydro-15-keto Prostaglandin F2α (13,14-dihydro-15-keto PGF2α) is the first prominent plasma metabolite of PGF2α in the 15-hydroxy PGDH pathway.
- GC46429 13,14-dihydro-15-keto Prostaglandin F2α-d4 An internal standard for the quantification of 13,14dihydro15keto PGF2α
- GC40625 13,14-dihydro-15-keto-tetranor Prostaglandin D2 A common metabolic pathway for several prostaglandins (PGs), including PGD2, involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs.
- GC40626 13,14-dihydro-15-keto-tetranor Prostaglandin E2 A common metabolic pathway for several prostaglandins (PG), including PGE2, involves the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs.
- GC41903 13,14-dihydro-15-keto-tetranor Prostaglandin F1α The metabolism of F series prostaglandins (PGs), including PGF1α and PGF2α, commonly begins with the reduction of the double bond between C-13 and C-14 and oxidation of the hydroxyl group at C-15, producing 13,14-dihydro-15-keto PGs.
- GC41904 13,14-dihydro-15-keto-tetranor Prostaglandin F1β 13,14-dihydro-15-keto tetranor-Prostaglandin F1β is a major urinary metabolite of PGE2 that is excreted in guinea pig urine at a concentration range of 1.34-2.74 μg/kg.
- GC41905 13,14-dihydro-16,16-difluoro Prostaglandin E1 Prostaglandin E1 (PGE1) is produced by the metabolism of dihomo-γ-linolenic acid (DGLA) by the cyclooxygenase pathway.
- GC41472 15(R),19(R)-hydroxy Prostaglandin E2 19(R)-Hydroxylated prostaglandins occur in μg/ml concentrations in the semen of certain mammalian species, especially primates.
- GC40532 15(R),19(R)-hydroxy Prostaglandin F2α 19(R)-Hydroxylated prostaglandins (PGs) occur in μg/ml concentrations in the semen of certain mammalian species, especially primates.
- GC41921 15(R)-15-methyl Prostaglandin A2 Arbaprostil (15(R)-15-methyl prostaglandin E2) is a synthetic prostaglandin E2 (PGE2) analog developed for its cytoprotective activity.
- GC41164 15(R)-15-methyl Prostaglandin D2 15(R)-15-methyl Prostaglandin D2 (15(R)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2.
- GC41165 15(R)-15-methyl Prostaglandin E2 15(R)-15-methyl Prostaglandin E2 (15(R)-15-methyl PGE2) is a prodrug for the potent PGE2 analog 15(S)-15-methyl PGE2.
- GC41440 15(R)-15-methyl Prostaglandin F2α 15(R)-15-methyl PGF2α is a metabolically stable analog of PGF2α.
- GC41244 15(R)-15-methyl Prostaglandin F2α methyl ester 15(R)-15-methyl Prostaglandin F2α methyl ester (15(R)-15-methyl PGF2α methyl ester) is a lipid soluble prodrug form of 15(R)-15-methyl PGF2α with increased membrane permeability.
- GC40988 15(R)-17-phenyl trinor Prostaglandin F2α 17-phenyl trinor Prostaglandin F2α N-ethyl amide (17-phenyl trinor PGF2α) is an F-series prostaglandin analog which has been approved for use as an ocular hypotensive drug, sold under the Allergan trade name 17-phenyl trinor PGF2α ethyl amide.
- GC40648 15(R)-17-phenyl trinor Prostaglandin F2α ethyl amide 15(R)-17-phenyl trinor Prostaglandin F2α ethyl amide (15(R)-17-phenyl trinor PGF2α ethyl amide) is an isomer of bimatoprost, characterized by an inverted (β) hydroxyl group at C-15.
- GC41922 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester 15(R)-17-phenyl trinor Prostaglandin F2α isopropyl ester (15(R)-17-phenyl trinor PGF2α isopropyl ester) is the latanoprost-related isomer containing both a double bond at 13,14 and an inverted (β) hydroxyl group at C-15.
- GC40972 15(R)-Iloprost Iloprost is a second generation structural analog of prostacyclin (PGI2) with about ten-fold greater potency than the first generation stable analogs, typified by carbaprostacyclin.
- GC41173 15(R)-Pinane Thromboxane A2 15(R)-Pinane thromboxane A2 is the (R)-epimer of pinane thromboxane A2.
- GC41416 15(R)-Prostaglandin D2 Many of the effects of prostaglandin D2 (PGD2) are transduced via a traditional 7-transmembrane GPCR, the DP1 receptor.
- GC18735 15(R)-Prostaglandin E1 15(R)-PGE1 is the unnatural-C-15 stereoisomer of PGE1.
- GC41417 15(R)-Prostaglandin E2 15(R)-Prostaglandin E2 (15(R)-PGE2) is the C-15 epimer of the naturally occurring 15(S)-PGE2.
- GC46439 15(R)-Prostaglandin F1α The C-15 epimer of PGF1α
- GC40581 15(R)-Prostaglandin F2α 15(R)-PGF2α is the C-15 epimer of the naturally occurring mammalian autacoid PGF2α.
- GC41166 15(S)-15-methyl Prostaglandin D2 15(S)-15-methyl Prostaglandin D2 (15(S)-15-methyl PGD2) is a metabolically stable synthetic analog of PGD2.
- GC18767 15(S)-15-methyl Prostaglandin E1 15(S)-15-methyl Prostaglandin E1 (15(S)-15-methyl PGE1) is a metabolically stable synthetic analog of PGE1 .
- GC41167 15(S)-15-methyl Prostaglandin E2 15(S)-15-methyl PGE2 is a potent, metabolically stable analog of PGE2.
- GC41924 15(S)-15-methyl Prostaglandin F2α isopropyl ester 15(S)-15-methyl Prostaglandin F2α (15(S)-15-methyl PGF2α) has been shown to have potent uterine stimulant and abortifacient properties when administered intramuscularly to induce labor.
- GC18372 15(S)-15-methyl Prostaglandin F2α methyl ester 15(S)-15-methyl PGF2α methyl ester is a derivative of 15(S)-15-methyl PGF2α with increased membrane permeability.
- GC40283 15(S)-Fluprostenol (+)-15(R)-Fluprostenol isopropyl ester is a prodrug (Travoprost) which is converted by esterase enzymatic activity in the cornea to yield the corresponding free acid.
- GC41589 15(S)-Fluprostenol isopropyl ester 15(S)-Fluprostenol isopropyl ester (15(S)-Flu-Ipr) is the unnatural C-15 epimer of Travoprost.
- GC46442 15(S)-HETE-d8 An internal standard for the quantification of 15-HETE
- GC41093 15(S)-Latanoprost 15(S)-Latanoprost is an analog of latanoprost in which the hydroxyl at carbon 15 is inverted relative to latanoprost.
- GC49036 15-(6-nitroxyhexanoyl)-17-phenyl trinor Prostaglandin F2α A nitric oxide-donating derivative of 17-phenyl trinor prostaglandin F2α
- GC41168 15-cyclohexyl pentanor Prostaglandin F2α 15-cyclohexyl pentanor PGF2α is an analog of PGF2α with resistance to 15-hydroxy PGDH metabolism.
- GC40375 15-deoxy-δ12,14-Prostaglandin A1 15-deoxy-δ12,14-Prostaglandin A1 (15-deoxy-δ12,14-PGA1) is a synthetic PGA1 analog.
- GC40350 15-deoxy-δ12,14-Prostaglandin A2 15-deoxy-δ12,14-PGA2 is a synthetic analog of PGA2.
- GC41928 15-deoxy-δ12,14-Prostaglandin J2 Glutathione 15-deoxy-δ12,14-Prostaglandin J2 Glutathione (15-deoxy-δ12,14-PGJ2 Glutathione) is a non-enzymatic adduct formed from 15-deoxy-δ12,14-PGJ2 and glutathione.
- GC46447 15-deoxy-δ12,14-Prostaglandin J2-d4 An internal standard for the quantification of 15deoxyΔ12,14prostaglandin J2
- GC41125 15-epi Prostaglandin A1 15-epi PGA1 is the 15(R) stereoisomer of PGA1.
- GC41933 15-keto Fluprostenol isopropyl ester 15-keto Fluprostenol isopropyl ester (15-Keto Fluprostenol isopropyl ester) is a metabolite of Travoprost.
- GC41934 15-keto Latanoprost Latanoprost is an F-series prostaglandin (PG) analog which has been approved for use as an ocular hypotensive drug.
- GC40989 15-keto Latanoprost (free acid) 15-keto Latanoprost is a potential metabolite of latanoprost when administered to animals.
- GC41103 15-keto Prostaglandin A1 Prostaglandin A1 (PGA1) was first isolated as a dehydration product of the PGE1 compounds found in human semen.