5(Z)-Dodecenoic Acid (Synonyms: C12:1 n-7, C12:1(5Z), cis-5-Dodecenoic Acid) |
| Catalog No.GC49499 |
5(Z)-Dodecenoic Acid is an endogenous metabolite with inhibitory activities against COX-I and COX-II.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2430-94-6
Sample solution is provided at 25 µL, 10mM.
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5(Z)-Dodecenoic acid is a medium-chain unsaturated fatty acid. It is a precursor in the biosynthesis of the sex pheromone 5(Z)-dodecenal.1 5(Z)-Dodecenoic acid levels are increased in culture medium from MCF-7 breast cancer cells compared to KMST-6 fibroblasts.2 Levels of 5(Z)-dodecenoic acid are increased in the plasma of patients with medium-chain acyl-CoA dehydrogenase (MCAD) deficiency, an inborn error of metabolism characterized by hypoketotic hypoglycemia, medium-chain dicarboxylic aciduria, and intolerance to fasting.3
1.Bestmann, H.J., Attygalle, A.B., Garbe, W., et al.Chemical structure and final steps of biosynthesis of the female sex pheromone of Gastropacha quercifolia (Lepidoptera: Lasiocampidae)Insect Biochem. Molec. Biol.23(7)793-799(1993) 2.Tanaka, M., Hsuan, C., Oeki, M., et al.Identification of characteristic compounds of moderate volatility in breast cancer cell linesPLoS One15(6)e0235442(2020) 3.Onkenhout, W., Venizelos, V., van der Poel, P.F.H., et al.Identification and quantification of intermediates of unsaturated fatty acid metabolism in plasma of patients with fatty acid oxidation disordersClin. Chem.41(10)1467-1474(1995)
| Cas No. | 2430-94-6 | SDF | |
| Synonyms | C12:1 n-7, C12:1(5Z), cis-5-Dodecenoic Acid | ||
| Canonical SMILES | CCCCCC/C=C\CCCC(O)=O | ||
| Formula | C12H22O2 | M.Wt | 198.3 |
| Solubility | Ethanol: 10 mg/ml | Storage | Store at -20°C,protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
|
1 mg | 5 mg | 10 mg |
| 1 mM | 5.0429 mL | 25.2143 mL | 50.4286 mL |
| 5 mM | 1.0086 mL | 5.0429 mL | 10.0857 mL |
| 10 mM | 0.5043 mL | 2.5214 mL | 5.0429 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL ddH2O, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 21 reference(s) in Google Scholar.)
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