6H05 (TFA) |
| Catalog No.GC60533 |
An allosteric inhibitor of oncogenic K-Ras(G12C)
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2061344-88-3
Sample solution is provided at 25 µL, 10mM.
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6H05 TFA is a selective, and allosteric inhibitor of oncogenic mutant K-Ras(G12C). IC50 value:Target: K-Ras G12C6H05 gives the greatest degree of modification, which allosterically modifies the oncogenic G12C mutant of highly homologous protein H-Ras without affecting wild-type K-Ras [1]. 6H05 can be used as an intermediate for the synthesis of other oncogenic K-Ras(G12C) inhibitors [2].
[1]. Ostrem JM, et al. K-Ras(G12C) inhibitors allosterically control GTP affinity and effector interactions. Nature. 2013 Nov 28;503(7477):548-51. [2]. Lu S, et al. Harnessing allostery: a novel approach to drug discovery. Med Res Rev. 2014 Nov;34(6):1242-85.
Average Rating: 5 (Based on Reviews and 11 reference(s) in Google Scholar.)
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