7β-hydroxy Cholesterol (Synonyms: 7β-Hydroxycholesterol) |
| Catalog No.GC40419 |
7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.
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Cas No.: 566-27-8
Sample solution is provided at 25 µL, 10mM.
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7β-hydroxy Cholesterol is an oxysterol formed by enzymatic and non-enzymatic oxidation of cholesterol.[1] It is the primary oxysterol found in LDL and induces apoptosis and cell death of human umbilical vein endothelial cells (HUVECs) in vitro in a concentration-dependent manner. Increased plasma levels of 7β-hydroxy cholesterol positively correlate with mortality in coronary heart disease in human males.[2]
Reference:
[1]. Lizard, G., Monier, S., Cordelet, C., et al. Characterization and comparison of the mode of cell death, apoptosis versus necrosis, induced by 7β-hydroxycholesterol and 7-ketocholesterol in the cells of the vascular wall. Arterioscler. Thromb. Vasc. Biol. 19(5), 1190-1200 (1999).
[2]. Ziedén, B., Kaminskas, A., Kristenson, M., et al. Increased plasma 7 β-hydroxycholesterol concentrations in a population with a high risk for cardiovascular disease. Artioscler.Thromb.Vasc.Biol. 19(4), 967-971 (1999).
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