Oleanolic Acid Acrylate (Synonyms: OAA) |
| Catalog No.GC45535 |
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1975976-24-9
Sample solution is provided at 25 µL, 10mM.
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Oleanolic acid acrylate (OAA) is an agonist of the serotonin (5-HT) receptor subtype 5-HT1A and a derivative of oleanolic acid .1 It acts as an agonist at the 5-HT1A receptor in mouse hippocampal homogenates in a [35S]GTPγS binding assay (EC50 = 0.79 μM). It is also a selective inhibitor of MAO-A over MAO-B (IC50s = 48.8 μM and >100 μM, respectively). In mice, OAA (10 mg/kg) reduces immobility in the forced swim test and increases the number of crossings and time spent at the center in the open field test, indicating anti-depressant-like and anxiolytic activities.
References
1. Fajemiroye, J.O., Polepally, P.R., Chaurasiya, N.D., et al. Oleanolic acid acrylate elicits antidepressant-like effect mediated by 5-HT1A receptor. Sci. Rep. 5, 11582 (2015).
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