ARD-2585 |
| Catalog No.GC63704 |
ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 2757422-79-8
Sample solution is provided at 25 µL, 10mM.
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ARD-2585 is an exceptionally potent and orally active PROTAC degrader of androgen receptor[1].
ARD-2585 achieves DC50 values of 0.04-0.1 nM in the VCaP cell line with AR gene amplification and in the LNCaP cell line carrying an AR mutation[1].ARD-2585 (100 nM) is effective in reducing the AR protein level at the 3 and 24 h time-points by 78% (p 0.05)[1].
[1]. Weiguo Xiang. et al. Discovery of ARD-2585 as an Exceptionally Potent and Orally Active PROTAC Degrader of Androgen Receptor for the Treatment of Advanced Prostate Cancer. J Med Chem. 2021 Sep 23;64(18):13487-13509.
Average Rating: 5 (Based on Reviews and 25 reference(s) in Google Scholar.)
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