Azvudine hydrochloride (Synonyms: RO-0622 hydrochloride; FNC hydrochloride) |
| Catalog No.GC60071 |
Azvudine hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI) that has antiviral activity against HIV, HBV, and HCV,(HIV-1 (EC50s 0.03 to 6.92 nM) and HIV-2 (EC50s 0.018 to 0.025 nM).
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Cas No.: 1333126-31-0
Sample solution is provided at 25 µL, 10mM.
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Azvudine hydrochloride is a potent nucleoside reverse transcriptase inhibitor (NRTI) that has antiviral activity against HIV, HBV, and HCV,(HIV-1 (EC50s 0.03 to 6.92 nM) and HIV-2 (EC50s 0.018 to 0.025 nM))[1]. Azivudine hydrochloride could inhibit SARS-CoV-2 and HCoV-OC43 coronavirus with EC50 1.2-4.3 µM[3].
In C8166 cells,Azvudine hydrochloride showed strong inhibition against wild-type HIV-1 IIIB and HIV-1 RF, with 50% effective concentration values (EC 50) ranging from 30 to 110 pM[2].
EV71 and CA16 challenge resulted in 90% and 30% mortality, respectively, while Azvudine hydrochloride treatment greatly reduced mortality to 20% and 0%. Azvudine hydrochloride treatment significantly improved clinical presentation and survival, indicating that Azvudine hydrochloride effectively protects against EV71 and CA16 challenge in vivo[4].
Treating SARS-CoV-2 infected rhesus macaques with Azvudine hydrochloride (0.07 mg/kg, qd, orally) reduced viral load, recuperated the thymus, improved lymphocyte profiles, alleviated inflammation and organ damage, and lessened ground-glass opacities in chest X-ray[3].
Azvudine hydrochloride clinical efficacy in curing COVID-19 was significant, showing inhibition of SARS-CoV-2 replication in all 31 patients after treatment with Azvudine hydrochloride, and the anti-coronavirus activity of Azvudine hydrochloride was also demonstrated in animal experiments using RM[5].
References:
[1]: Wang RR, Yang QH, et,al. Azvudine, a novel nucleoside reverse transcriptase inhibitor showed good drug combination features and better inhibition on drug-resistant strains than lamivudine in vitro. PLoS One. 2014 Aug 21;9(8):e105617. doi: 10.1371/journal.pone.0105617. PMID: 25144636; PMCID: PMC4140803.
[2]: Zhou Y, Zhang Y, et,al.Novel nucleoside analogue FNC is effective against both wild-type and lamivudine-resistant HBV clinical isolates. Antivir Ther. 2012;17(8):1593-9. doi: 10.3851/IMP2292. Epub 2012 Aug 9. PMID: 22910281.
[3]: Zhang JL, Li YH, et,al. Azvudine is a thymus-homing anti-SARS-CoV-2 drug effective in treating COVID-19 patients. Signal Transduct Target Ther. 2021 Dec 6;6(1):414. doi: 10.1038/s41392-021-00835-6. PMID: 34873151; PMCID: PMC8646019.
[4]: Xu N, Yang J, et,al.The Pyrimidine Analog FNC Potently Inhibits the Replication of Multiple Enteroviruses. J Virol. 2020 Apr 16;94(9):e00204-20. doi: 10.1128/JVI.00204-20. PMID: 32075935; PMCID: PMC7163137.
[5]: Ren Z, Luo H, et,al. A Randomized, Open-Label, Controlled Clinical Trial of Azvudine Tablets in the Treatment of Mild and Common COVID-19, a Pilot Study. Adv Sci (Weinh). 2020 Aug 13;7(19):2001435. doi: 10.1002/advs.202001435. PMID: 32837847; PMCID: PMC7404576.
[6]: Fayzullina D, Kharwar RK, et,al. FNC: An Advanced Anticancer Therapeutic or Just an Underdog? Front Oncol. 2022 Feb 10;12:820647. doi: 10.3389/fonc.2022.820647. PMID: 35223502; PMCID: PMC8867032.
Average Rating: 5 (Based on Reviews and 29 reference(s) in Google Scholar.)
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