Benzisoxazole Hsp90 Inhibitor (Synonyms: BHI) |
| Catalog No.GC41532 |
Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1012788-65-6
Sample solution is provided at 25 µL, 10mM.
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Heat shock protein 90 (Hsp90) is a molecular chaperone that modulates intracellular signaling and protein folding, trafficking, and turnover. Inhibitors of Hsp90, such as geldanamycin, have shown promise as anti-tumor agents. Benzisoxazole Hsp90 inhibitor binds the N-terminal domain of Hsp90, efficiently displacing geldanamycin from the ATP binding site (IC50 = 30 nM). In addition, Benzisoxazole Hsp90 inhibitor inhibits the proliferation of several cancer cell lines (IC50 ~ 0.28 μM), promotes the degradation of the Hsp90 client proteins Her-2 and androgen receptor, and has no effect on a variety of kinases.
Average Rating: 5 (Based on Reviews and 23 reference(s) in Google Scholar.)
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