Bevurogant (Synonyms: BI 730357) |
Catalog No.GC63436
One-Click Copy Product Info
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Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist.
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: 1817773-66-2
Sample solution is provided at 25 µL, 10mM.
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Bevurogant (BI 730357) is a retinoid-related orphan receptor-gamma t (RORγt) antagonist[1]. Retinoic acid-related orphan receptors (RORs, including RORα, RORβ, and RORγ) act as transcription factors upon binding with their ligands. RORγt, a subtype of RORγ, promotes Th17 cell responses through transcription of IL-17A, IL-17F, IL-22, and IL-23R[2]. Bevurogant is used in research on chronic inflammatory diseases such as psoriasis[3].
References:
[1] Choi H J, Madari S, Huang F. Utilising Endogenous Biomarkers in Drug Development to Streamline the Assessment of Drug–Drug Interactions Mediated by Renal Transporters: A Pharmaceutical Industry Perspective[J]. Clinical Pharmacokinetics, 2024: 1-15.
[2] Carmona-Rocha E, Rusiñol L, Puig L. New and emerging oral/topical small-molecule treatments for psoriasis[J]. Pharmaceutics, 2024, 16(2): 239.
[3] Ooi Q X, Kristoffersson A, Korell J, et al. Bounded integer model‐based analysis of psoriasis area and severity index in patients with moderate‐to‐severe plaque psoriasis receiving BI 730357[J]. CPT: Pharmacometrics & Systems Pharmacology, 2023, 12(6): 758-769.
| Cas No. | 1817773-66-2 | SDF | |
| Synonyms | BI 730357 | ||
| Formula | C26H28N8O3S | M.Wt | 532.62 |
| Solubility | DMSO : 250 mg/mL (469.38 mM; Need ultrasonic) | Storage | Store at -20°C |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8775 mL | 9.3876 mL | 18.7751 mL |
| 5 mM | 375.5 μL | 1.8775 mL | 3.755 mL |
| 10 mM | 187.8 μL | 938.8 μL | 1.8775 mL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
g
μL
Step 2: Enter the in vivo formulation (This is only the calculator, not formulation. Please contact us first if there is no in vivo formulation at the solubility Section.)
Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.50% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 26 reference(s) in Google Scholar.)