C18 Ganglioside GM1-d3 (d18:1/18:0-d3) (ammonium salt) (Synonyms: N-omega-CD3-Octadecanoyl monosialoganglioside GM1-d3, N-CD3-Stearoyl-GM, C18 GM1-d3, GM1 (18:1/18:0-d3), GM1 (d18:1/C18:0)-d3, Monosialoganglioside GM1-d3, N-Stearoyl Monosialoganglioside GM1-d3) |
Catalog No.GC46992
One-Click Copy Product Info
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A neuropeptide with diverse biological activities
Products are for research use only. Not for human use. We do not sell to patients.
Cas No.: N/A
Sample solution is provided at 25 µL, 10mM.
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C18 Ganglioside GM1-d3 (d18:1/18:0-d3) is intended for use as an internal standard for the quantification of C18 ganglioside GM1. Ganglioside GM1 is a monosialylated ganglioside and the prototypic ganglioside for those containing one sialic acid residue.1,2 C18 Ganglioside GM1 is found in the brain, primarily in the piriform cortex, amygdala nucleus, striatum, and hippocampal CA1 region.3 The ratio of C18 ganglioside GM1 (d20:1/18:0) to C18 ganglioside GM1 is decreased in the outer molecular layer of the hippocampal dentate gyrus in postmortem tissue from patients with Alzheimer's disease.4 [Matreya, LLC. Catalog No. 2050]
1.Kolter, T.Ganglioside biochemistryISRN Biochem.506160(2012) 2.Mocchetti, I.Exogenous gangliosides, neuronal plasticity and repair, and the neurotrophinsCell Mol. Life Sci.62(19-20)2283-2294(2005) 3.Andres, A.D., Young, L.E.A., Gentry, M.S., et al.Spatial profiling of gangliosides in mouse brain by mass spectrometry imagingJ. Lipid Res.(2020) 4.Hirano-Sakamaki, W., Sugiyama, E., Hayasaka, T., et al.Alzheimer's disease is associated with disordered localization of ganglioside GM1 molecular species in the human dentate gyrusFEBS Lett.589(23)3611-3616(2015)
| Cas No. | N/A | SDF | |
| Synonyms | N-omega-CD3-Octadecanoyl monosialoganglioside GM1-d3, N-CD3-Stearoyl-GM, C18 GM1-d3, GM1 (18:1/18:0-d3), GM1 (d18:1/C18:0)-d3, Monosialoganglioside GM1-d3, N-Stearoyl Monosialoganglioside GM1-d3 | ||
| Canonical SMILES | OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@@]2([H])[C@@H]([C@@]([C@H]([C@H](O2)CO)O[C@]3([H])O[C@@H]([C@@H]([C@@H]([C@H]3NC(C)=O)O[C@@]4([H])[C@@H]([C@H]([C@H]([C@H](O4)CO)O)O)O)O)CO)([H])O[C@]5(C([O-])=O)C[C@H](O)[C@@H](NC(C)=O)[C@H]([C@@H]([C@H](O)CO)O)O5)O)O[C@H]1OC[C@@H]([C@H](O)/C=C/CCCCCCCCCCCCC)NC(CCCCCCCCCCCCCCCCC([2H])([2H])[2H])=O.[NH4+] | ||
| Formula | C73H127D3N3O31.NH4 | M.Wt | 1566.9 |
| Solubility | Chloroform:Methanol:Water (2:1:0.1): Soluble | Storage | Store at -20°C, protect from light |
| General tips | Please select the appropriate solvent to prepare the stock solution according to the
solubility of the product in different solvents; once the solution is prepared, please store it in
separate packages to avoid product failure caused by repeated freezing and thawing.Storage method
and period of the stock solution: When stored at -80°C, please use it within 6 months; when stored
at -20°C, please use it within 1 month. To increase solubility, heat the tube to 37°C and then oscillate in an ultrasonic bath for some time. |
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| Shipping Condition | Evaluation sample solution: shipped with blue ice. All other sizes available: with RT, or with Blue Ice upon request. | ||
| Prepare stock solution | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 638.2 μL | 3.191 mL | 6.382 mL |
| 5 mM | 127.6 μL | 638.2 μL | 1.2764 mL |
| 10 mM | 63.8 μL | 319.1 μL | 638.2 μL |
Step 1: Enter information below (Recommended: An additional animal making an allowance for loss during the experiment)
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μL
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Calculation results:
Working concentration: mg/ml;
Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO ( Master liquid concentration mg/mL, Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug. )
Method for preparing in vivo formulation: Take μL DMSO master liquid, next addμL PEG300, mix and clarify, next addμL Tween 80, mix and clarify, next add μL saline, mix and clarify.
Method for preparing in vivo formulation: Take μL DMSO master liquid, next add μL Corn oil, mix and clarify.
Note: 1. Please make sure the liquid is clear before adding the next solvent.
2. Be sure to add the solvent(s) in order. You must ensure that the solution obtained, in the previous addition, is a clear solution before proceeding to add the next solvent. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.
3. All of the above co-solvents are available for purchase on the GlpBio website.
Quality Control & SDS
- View current batch:
- Purity: >99.00% Appearance: A solid
- COA (Certificate of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Average Rating: 5 (Based on Reviews and 7 reference(s) in Google Scholar.)