17-phenyl trinor Prostaglandin F2α-d4 (Synonyms: Bimatoprost (free acid)d4, 17phenyl trinor PGF2αd4)

17-phenyl trinor Prostaglandin F_2α-d₄ (17-phenyl trinor PGF_2α-d₄) contains four deuterium atoms at the 3, 3', 4, and 4' positions. It is intended for use as an internal standard for the quantification of 17-phenyl trinor PGF_2α by GC- or LC-mass spectrometry. 17-phenyl trinor PGF_2α is a metabolically stable analog of PGF_2α and is a potent agonist for the FP receptor. It binds to the FP receptor on ovine luteal cells with a relative potency of 756% compared to that of PGF_2α.¹ At the rat recombinant FP receptor expressed in CHO cells 17-phenyl trinor PGF_2α inhibits PGF_2α binding with a K_i of 1.1 nM.² The isopropyl ester of 17-phenyl trinor PGF_2α-d₄ is slightly better than PGF_2α isopropyl ester in reducing the intraocular pressure in the cat eye without any irritation.³

1.Balapure, A.K., Rexroad, C.E., Jr., Kawada, K., et al.Structural requirements for prostaglandin analog interaction with the ovine corpus luteum prostaglandin F2α receptorBiochem. Pharmacol.38(14)2375-2381(1989) 2.Lake, S., Gullberg, H., Wahlqvist, J., et al.Cloning of the rat and human prostaglandin F2α receptors and the expression of the rat prostaglandin F2α receptorFEBS Letters355317-325(1994) 3.Stjernschantz, J., and Resul, B.Phenyl substituted prostaglandin analogs for glaucoma treatmentDrugs of the Future17691-704(1992)